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Prx3 Peroxiredoxin 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42109, updated on 9-Dec-2024

Summary

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Official Symbol
Prx3provided by FlyBase
Official Full Name
Peroxiredoxin 3provided by FlyBase
Primary source
FLYBASE:FBgn0038519
Locus tag
Dmel_CG5826
See related
AllianceGenome:FB:FBgn0038519
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5826; Dmel\CG5826; dPRDX3; dprx3; dPrx3; DPx-5037; DPx5037; mTPx; mtTPx; peroxiredoxin 5037; Prx5037
Summary
Enables thioredoxin-dependent peroxiredoxin activity. Involved in several processes, including cell redox homeostasis; determination of adult lifespan; and hydrogen peroxide catabolic process. Located in mitochondrion. Is expressed in adult head; adult heart; adult thorax; and organism. Used to study autosomal recessive spinocerebellar ataxia 32. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 32. Orthologous to human PRDX3 (peroxiredoxin 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Prx3 in Genome Data Viewer
Location:
90B4-90B4; 3-61 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17545222..17546531, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13370944..13372253, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene lethal (3) 07882 Neighboring gene Pyrroline-5-carboxylate reductase-like 2 Neighboring gene Splicing factor 1 Neighboring gene H6-like-homeobox Neighboring gene Sgs5bis

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Involvement of Prx3, a Drosophila ortholog of the thiol-dependent peroxidase PRDX3, in age-dependent oxidative stress resistance. Kayashima Y, et al. Biomed Res, 2012. PMID 23124252
  2. Thioredoxin peroxidases can foster cytoprotection or cell death in response to different stressors: over- and under-expression of thioredoxin peroxidase in Drosophila cells. Radyuk SN, et al. Biochem J, 2003 May 1. PMID 12556226, Free PMC Article
  3. Supplementation with hydrogen-producing composition confers beneficial effects on physiology and life span in Drosophila. Klichko VI, et al. Heliyon, 2019 May. PMID 31193183, Free PMC Article
  4. Biallelic loss-of-function variations in PRDX3 cause cerebellar ataxia. Rebelo AP, et al. Brain, 2021 Jun 22. PMID 33889951
  5. Mitochondrial Redox Signaling Is Critical to the Normal Functioning of the Neuronal System. Odnokoz O, et al. Front Cell Dev Biol, 2021. PMID 33585478, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biallelic loss-of-function variations in PRDX3 cause cerebellar ataxia.
    Title: Biallelic loss-of-function variations in PRDX3 cause cerebellar ataxia.
  2. Data shows that LRRK2 inhibits PRDX3 in the fly brain.
    Title: Thiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in Drosophila.
  3. Prx3 plays an important role in the oxidative stress response and is involved in the age-dependent competence of the oxidative stress response.
    Title: Involvement of Prx3, a Drosophila ortholog of the thiol-dependent peroxidase PRDX3, in age-dependent oxidative stress resistance.
  4. flies underexpressing peroxiredoxin 3 and peroxiredoxin 5 showed an 80% reduction in lifespan and a massive induction of apoptosis in the muscle and digestive system tissues.
    Title: Mitochondrial peroxiredoxins are critical for the maintenance of redox state and the survival of adult Drosophila.
  5. While the upstream CG7215 gene can be expressed from both mono- and dicistronic mRNAs, the downstream dPrx5 gene is likely to be expressed predominantly from its monocistronic transcripts.
    Title: Drosophila peroxiredoxin 5 is the second gene in a dicistronic operon.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables peroxiredoxin activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
  
enables thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioredoxin-dependent peroxiredoxin activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell redox homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix TAS
Traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
peroxiredoxin 3
Names
CG5826-PA
Prx3-PA
mitochondrial peroxiredoxin
peroxiredoxin 5037
thioredoxin peroxidase 3
thioredoxin-peroxidase-3
NP_524387.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    17545222..17546531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079663.3 → NP_524387.1  peroxiredoxin 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524387.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9GPQ3, Q9VEJ0
    Related
    FBpp0082927
    Conserved Domains (3) summary
    COG0450
    Location:40 → 233
    AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
    cd03015
    Location:42 → 212
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
    pfam10417
    Location:195 → 232
    1-cysPrx_C; C-terminal domain of 1-Cys peroxiredoxin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VEJ0.2 Q9VEJ0

Gene LinkOut

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