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FANCL Fanconi anemia complementation group L [ Gallus gallus (chicken) ]

Gene ID: 421202, updated on 3-Dec-2024

Summary

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Symbol
FANCLprovided by CGNC
Full Name
Fanconi anemia complementation group Lprovided by CGNC
Primary source
CGNC:5961
See related
Ensembl:ENSGALG00010017104
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See FANCL in Genome Data Viewer
Location:
chromosome: 3
Exon count:
16
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (1003650..1032154, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (970148..998660, complement)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112532111 Neighboring gene microRNA 6583 Neighboring gene uncharacterized LOC121110468 Neighboring gene VRK serine/threonine kinase 2 Neighboring gene uncharacterized LOC101748294 Neighboring gene microRNA 7463 Neighboring gene uncharacterized LOC112532195

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A requirement of FancL and FancD2 monoubiquitination in DNA repair. Seki S, et al. Genes Cells, 2007 Mar. PMID 17352736
  2. A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair. Matsushita N, et al. Mol Cell, 2005 Sep 16. PMID 16168378
  3. Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway. Rosado IV, et al. Nat Struct Mol Biol, 2011 Nov 13. PMID 22081012
  4. DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI. Sato K, et al. Nucleic Acids Res, 2012 May. PMID 22287633, Free PMC Article
  5. Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair. Sato K, et al. EMBO J, 2012 Aug 29. PMID 22828868, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in interstrand cross-link repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein monoubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of Fanconi anaemia nuclear complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase FANCL
Names
FA complementation group L
Fanconi anemia protein FANCL
NP_001029113.1
XP_025004391.1
XP_025004392.1
XP_046769449.1
XP_046769450.1
XP_046769451.1
XP_046769452.1
XP_046769453.1
XP_046769454.1
XP_046769455.1
XP_046769456.1
XP_046769457.1
XP_046769458.1
XP_046794616.1
XP_046794617.1
XP_046794618.1
XP_046794619.1
XP_046794620.1
XP_046794621.1
XP_046794622.1
XP_046794623.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033941.2 → NP_001029113.1  E3 ubiquitin-protein ligase FANCL

    See identical proteins and their annotated locations for NP_001029113.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000059
    UniProtKB/TrEMBL
    A0A8V0YZE4, Q3MUH5
    Related
    ENSGALP00010024177.1, ENSGALT00010041290.1
    Conserved Domains (4) summary
    pfam09765
    Location:6 → 92
    WD-3; WD-repeat region
    pfam11793
    Location:301 → 369
    FANCL_C; FANCL C-terminal domain
    pfam18890
    Location:106 → 195
    FANCL_d2; FANCL UBC-like domain 2
    pfam18891
    Location:197 → 293
    FANCL_d3; FANCL UBC-like domain 3

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    1003650..1032154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046938666.1 → XP_046794622.1  E3 ubiquitin-protein ligase FANCL isoform X2

    UniProtKB/TrEMBL
    A0A8V0YZE4

  2. XM_046938663.1 → XP_046794619.1  E3 ubiquitin-protein ligase FANCL isoform X1

    UniProtKB/TrEMBL
    A0A8V0YZE4

  3. XM_025148624.3 → XP_025004392.1  E3 ubiquitin-protein ligase FANCL isoform X2

    UniProtKB/TrEMBL
    A0A8V0YZE4
    Conserved Domains (3) summary
    pfam09765
    Location:3 → 243
    WD-3; WD-repeat region
    pfam11793
    Location:251 → 319
    FANCL_C; FANCL C-terminal domain
    cd16490
    Location:255 → 310
    RING-CH-C4HC3_FANCL; RING-CH finger (C4HC3-type) [structural motif]

  4. XM_046938661.1 → XP_046794617.1  E3 ubiquitin-protein ligase FANCL isoform X1

    UniProtKB/TrEMBL
    A0A8V0YZE4

  5. XM_046938665.1 → XP_046794621.1  E3 ubiquitin-protein ligase FANCL isoform X2

    UniProtKB/TrEMBL
    A0A8V0YZE4

  6. XM_046938662.1 → XP_046794618.1  E3 ubiquitin-protein ligase FANCL isoform X1

    UniProtKB/TrEMBL
    A0A8V0YZE4

  7. XM_046938667.1 → XP_046794623.1  E3 ubiquitin-protein ligase FANCL isoform X2

    UniProtKB/TrEMBL
    A0A8V0YZE4

  8. XM_025148623.3 → XP_025004391.1  E3 ubiquitin-protein ligase FANCL isoform X1

    UniProtKB/TrEMBL
    A0A8V0YZE4
    Conserved Domains (3) summary
    pfam09765
    Location:9 → 251
    WD-3; WD-repeat region
    pfam11793
    Location:259 → 327
    FANCL_C; FANCL C-terminal domain
    cd16490
    Location:263 → 318
    RING-CH-C4HC3_FANCL; RING-CH finger (C4HC3-type) [structural motif]

  9. XM_046938664.1 → XP_046794620.1  E3 ubiquitin-protein ligase FANCL isoform X2

    UniProtKB/TrEMBL
    A0A8V0YZE4

  10. XM_046938660.1 → XP_046794616.1  E3 ubiquitin-protein ligase FANCL isoform X1

    UniProtKB/TrEMBL
    A0A8V0YZE4

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    970148..998660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046913501.1 → XP_046769457.1  E3 ubiquitin-protein ligase FANCL isoform X2

    UniProtKB/TrEMBL
    A0A8V0YZE4

  2. XM_046913497.1 → XP_046769453.1  E3 ubiquitin-protein ligase FANCL isoform X1

    UniProtKB/TrEMBL
    A0A8V0YZE4

  3. XM_046913498.1 → XP_046769454.1  E3 ubiquitin-protein ligase FANCL isoform X2

    UniProtKB/TrEMBL
    A0A8V0YZE4

  4. XM_046913494.1 → XP_046769450.1  E3 ubiquitin-protein ligase FANCL isoform X1

    UniProtKB/TrEMBL
    A0A8V0YZE4

  5. XM_046913500.1 → XP_046769456.1  E3 ubiquitin-protein ligase FANCL isoform X2

    UniProtKB/TrEMBL
    A0A8V0YZE4

  6. XM_046913495.1 → XP_046769451.1  E3 ubiquitin-protein ligase FANCL isoform X1

    UniProtKB/TrEMBL
    A0A8V0YZE4

  7. XM_046913502.1 → XP_046769458.1  E3 ubiquitin-protein ligase FANCL isoform X2

    UniProtKB/TrEMBL
    A0A8V0YZE4

  8. XM_046913496.1 → XP_046769452.1  E3 ubiquitin-protein ligase FANCL isoform X1

    UniProtKB/TrEMBL
    A0A8V0YZE4

  9. XM_046913499.1 → XP_046769455.1  E3 ubiquitin-protein ligase FANCL isoform X2

    UniProtKB/TrEMBL
    A0A8V0YZE4

  10. XM_046913493.1 → XP_046769449.1  E3 ubiquitin-protein ligase FANCL isoform X1

    UniProtKB/TrEMBL
    A0A8V0YZE4
Nucleotide Protein Strain
Heading Accession and Version

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