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LTBP1 latent transforming growth factor beta binding protein 1 [ Gallus gallus (chicken) ]

Gene ID: 421461, updated on 3-Dec-2024

Summary

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Symbol
LTBP1provided by CGNC
Full Name
latent transforming growth factor beta binding protein 1provided by CGNC
Primary source
CGNC:51489
See related
Ensembl:ENSGALG00010007719
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See LTBP1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
33
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (30814381..30996860, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (30742332..30924844, complement)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124417805 Neighboring gene uncharacterized LOC107052897 Neighboring gene family with sequence similarity 98 member A Neighboring gene RAS guanyl releasing protein 3 Neighboring gene uncharacterized LOC121110321 Neighboring gene uncharacterized LOC107052896 Neighboring gene uncharacterized LOC112532173 Neighboring gene tetratricopeptide repeat domain 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Marek's disease virus-encoded analog of microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-β signaling pathway. Chi JQ, et al. Virology, 2015 Feb. PMID 25528440
  2. Tgfbeta2 and 3 are coexpressed with their extracellular regulator Ltbp1 in the early limb bud and modulate mesodermal outgrowth and BMP signaling in chicken embryos. Lorda-Diez CI, et al. BMC Dev Biol, 2010 Jun 21. PMID 20565961, Free PMC Article
  3. Non-coding RNAs revealed during identification of genes involved in chicken immune responses. Ahanda ML, et al. Immunogenetics, 2009 Jan. PMID 19009289
  4. Analysis of chicken embryonic gonad expressed sequenced tags. Shin JH, et al. Anim Genet, 2006 Feb. PMID 16441308
  5. Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index. Carre W, et al. Physiol Genomics, 2006 May 16. PMID 16554550

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Marek's disease virus microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-beta signaling pathway.
    Title: Marek's disease virus-encoded analog of microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-β signaling pathway.
  2. Latent Tgfbeta Binding protein 1 (LTBP1), which is a key extracellular modulator of Tgfbeta ligand bioavailability, is coexpressed with Tgfbetas in the chicken early limb bud.
    Title: Tgfbeta2 and 3 are coexpressed with their extracellular regulator Ltbp1 in the early limb bud and modulate mesodermal outgrowth and BMP signaling in chicken embryos.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
latent-transforming growth factor beta-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398250.1 → NP_001385179.1  latent-transforming growth factor beta-binding protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000063
    UniProtKB/TrEMBL
    A0A8V0XPE8
    Related
    ENSGALP00010010062.1, ENSGALT00010018374.1
    Conserved Domains (3) summary
    smart00179
    Location:1140 → 1181
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:977 → 1010
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    TIGR02813
    Location:709 → 827
    omega_3_PfaA; polyketide-type polyunsaturated fatty acid synthase PfaA

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    30814381..30996860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015283725.4 → XP_015139211.2  latent-transforming growth factor beta-binding protein 1 isoform X6

    Conserved Domains (2) summary
    smart00179
    Location:1061 → 1102
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:898 → 931
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  2. XM_015283724.4 → XP_015139210.2  latent-transforming growth factor beta-binding protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8V0XVP9
    Related
    ENSGALP00010010064.1, ENSGALT00010018377.1
    Conserved Domains (2) summary
    smart00179
    Location:1062 → 1103
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:899 → 932
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  3. XM_015283723.4 → XP_015139209.2  latent-transforming growth factor beta-binding protein 1 isoform X4

    Conserved Domains (2) summary
    smart00179
    Location:1085 → 1126
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:922 → 955
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  4. XM_015283721.4 → XP_015139207.2  latent-transforming growth factor beta-binding protein 1 isoform X1

    Conserved Domains (3) summary
    smart00179
    Location:1139 → 1180
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:976 → 1009
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    TIGR02813
    Location:709 → 826
    omega_3_PfaA; polyketide-type polyunsaturated fatty acid synthase PfaA

  5. XM_025148694.3 → XP_025004462.2  latent-transforming growth factor beta-binding protein 1 isoform X2

    Conserved Domains (3) summary
    smart00179
    Location:1099 → 1140
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:977 → 1010
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    TIGR02813
    Location:709 → 827
    omega_3_PfaA; polyketide-type polyunsaturated fatty acid synthase PfaA

  6. XM_015283722.4 → XP_015139208.2  latent-transforming growth factor beta-binding protein 1 isoform X3

    Conserved Domains (3) summary
    smart00179
    Location:1140 → 1181
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:977 → 1010
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    TIGR02813
    Location:709 → 827
    omega_3_PfaA; polyketide-type polyunsaturated fatty acid synthase PfaA

  7. XM_046938825.1 → XP_046794781.1  latent-transforming growth factor beta-binding protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A8V0XTQ7

  8. XM_046938824.1 → XP_046794780.1  latent-transforming growth factor beta-binding protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A8V0XTQ7

  9. XM_040697088.2 → XP_040553022.1  latent-transforming growth factor beta-binding protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8V0XTQ7
    Related
    ENSGALP00010010061.1, ENSGALT00010018365.1
    Conserved Domains (2) summary
    smart00179
    Location:782 → 823
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:619 → 652
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  10. XM_046938823.1 → XP_046794779.1  latent-transforming growth factor beta-binding protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8V0XTQ7

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    30742332..30924844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046913844.1 → XP_046769800.1  latent-transforming growth factor beta-binding protein 1 isoform X6

  2. XM_046913843.1 → XP_046769799.1  latent-transforming growth factor beta-binding protein 1 isoform X5

  3. XM_046913842.1 → XP_046769798.1  latent-transforming growth factor beta-binding protein 1 isoform X4

  4. XM_046913839.1 → XP_046769795.1  latent-transforming growth factor beta-binding protein 1 isoform X1

  5. XM_046913840.1 → XP_046769796.1  latent-transforming growth factor beta-binding protein 1 isoform X2

  6. XM_046913841.1 → XP_046769797.1  latent-transforming growth factor beta-binding protein 1 isoform X3

  7. XM_046913848.1 → XP_046769804.1  latent-transforming growth factor beta-binding protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A8V0XTQ7

  8. XM_046913847.1 → XP_046769803.1  latent-transforming growth factor beta-binding protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A8V0XTQ7

  9. XM_046913846.1 → XP_046769802.1  latent-transforming growth factor beta-binding protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8V0XTQ7

  10. XM_046913849.1 → XP_046769805.1  latent-transforming growth factor beta-binding protein 1 isoform X11

    UniProtKB/TrEMBL
    A0A8V0XTQ7

  11. XM_046913845.1 → XP_046769801.1  latent-transforming growth factor beta-binding protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8V0XTQ7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001282608.2: Suppressed sequence

    Description
    NM_001282608.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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