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GREM2 gremlin 2, DAN family BMP antagonist [ Gallus gallus (chicken) ]

Gene ID: 421507, updated on 3-Dec-2024

Summary

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Symbol
GREM2provided by CGNC
Full Name
gremlin 2, DAN family BMP antagonistprovided by CGNC
Primary source
CGNC:8191
See related
Ensembl:ENSGALG00010008824
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See GREM2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
3
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (35840633..35883040)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (35744415..35787737)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis class M Neighboring gene regulator of G protein signaling 7 Neighboring gene formin 2 Neighboring gene uncharacterized LOC121110227

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The oncoprotein v-Myb activates transcription of Gremlin 2 during in vitro differentiation of the chicken neural crest to melanoblasts. Starostová M, et al. Gene, 2014 Apr 25. PMID 24576577
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of Gremlin 2 in neural crest cells does not promote formation of melanocytes suggesting that Gremlin 2 is not the master regulator of melanocytic differentiation.
    Title: The oncoprotein v-Myb activates transcription of Gremlin 2 during in vitro differentiation of the chicken neural crest to melanoblasts.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables BMP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor ligand activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sequestering of BMP from receptor via BMP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
gremlin-2
Names
gremlin 2, cysteine knot superfamily, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    35840633..35883040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046939102.1 → XP_046795058.1  gremlin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y148

  2. XM_419552.8 → XP_419552.3  gremlin-2 isoform X2

    UniProtKB/TrEMBL
    A0A3Q3AYA9, A0A8V0Y148
    Related
    ENSGALP00010012046.1, ENSGALT00010020965.1
    Conserved Domains (1) summary
    pfam03045
    Location:51 → 158
    DAN; DAN domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    35744415..35787737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046914548.1 → XP_046770504.1  gremlin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y148

  2. XM_040666920.2 → XP_040522854.1  gremlin-2 isoform X2

    UniProtKB/TrEMBL
    A0A3Q3AYA9, A0A8V0Y148
    Conserved Domains (1) summary
    pfam03045
    Location:51 → 158
    DAN; DAN domain

  3. XM_046914549.1 → XP_046770505.1  gremlin-2 isoform X2

    UniProtKB/TrEMBL
    A0A3Q3AYA9, A0A8V0Y148

  4. XM_046914550.1 → XP_046770506.1  gremlin-2 isoform X2

    UniProtKB/TrEMBL
    A0A3Q3AYA9, A0A8V0Y148
Nucleotide Protein
Heading Accession and Version

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