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sr stripe [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42162, updated on 4-Jan-2025

Summary

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Official Symbol
srprovided by FlyBase
Official Full Name
stripeprovided by FlyBase
Primary source
FLYBASE:FBgn0003499
Locus tag
Dmel_CG7847
See related
AllianceGenome:FB:FBgn0003499
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7847; Dmel\CG7847; l(3)03999; l(3)06948; l(3)06948b; Sr; SrB; Stripe
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SUMO ligase activity. Involved in several processes, including ectoderm development; epithelial cell migration, open tracheal system; and germ-band shortening. Is expressed in several structures, including denticle row; imaginal disc; muscle attachment site; region of integument; and sensory organ cell. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1) and EGR3 (early growth response 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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Location:
90E4-90F1; 3-62 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18090803..18135583)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13916525..13961305)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene heartless Neighboring gene bard Neighboring gene transfer RNA:Glycine-TCC 1-3 Neighboring gene transfer RNA:Glycine-TCC 1-4 Neighboring gene long non-coding RNA:CR45103 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a Drosophila muscle development gene with structural homology to mammalian early growth response transcription factors. Lee JC, et al. Proc Natl Acad Sci U S A, 1995 Oct 24. PMID 7479781, Free PMC Article
  2. Neurophysiology of flight in wild-type and a mutant Drosophila. Levine JD, et al. Proc Natl Acad Sci U S A, 1973 Apr. PMID 4197927, Free PMC Article
  3. Development of an indirect flight muscle in a muscle-specific mutant of Drosophila melanogaster. Costello WJ, et al. Dev Biol, 1986 Nov. PMID 3095162
  4. Two isoforms of the Drosophila RNA binding protein, how, act in opposing directions to regulate tendon cell differentiation. Nabel-Rosen H, et al. Dev Cell, 2002 Feb. PMID 11832244
  5. The bristle patterning genes hairy and extramacrochaetae regulate the development of structures required for flight in Diptera. Costa M, et al. Dev Biol, 2014 Apr 15. PMID 24384389, Free PMC Article

See all (206) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cell assembly analysis of neural circuits for innate behavior in Drosophila melanogaster using an immediate early gene stripe/egr-1.
    Title: Cell assembly analysis of neural circuits for innate behavior in Drosophila melanogaster using an immediate early gene stripe/egr-1.
  2. The positioning and differentiation of the migrating chordotonal organs are instructed by Stripe.
    Title: The proprioceptive and contractile systems in Drosophila are both patterned by the EGR family transcription factor Stripe.
  3. role in providing cues synergizing with branchless to direct tracheal cell migration
    Title: Stripe provides cues synergizing with branchless to direct tracheal cell migration.
  4. the transition to the mature differentiation state is triggered post-transcriptionally by enhanced production of the stripeA splice variant, which is typical of the tendon mature state
    Title: Muscle-dependent maturation of tendon cells is induced by post-transcriptional regulation of stripeA.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ectoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell migration, open tracheal system IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in epithelial cell migration, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-band shortening IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pigment metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein sumoylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
stripe
Names
CG7847-PA
CG7847-PB
CG7847-PC
CG7847-PD
CG7847-PE
STRIPE
StripeB
sr-PA
sr-PB
sr-PC
sr-PD
sr-PE
striped

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    18090803..18135583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079671.2 → NP_524395.2  stripe, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524395.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JP26, Q9VED3
    Related
    FBpp0082966, FBtr0083542
    Conserved Domains (3) summary
    sd00017
    Location:1038 → 1060
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1036 → 1060
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1080 → 1105
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001275764.1 → NP_001262693.1  stripe, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262693.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGW2, Q7JP26
    Conserved Domains (3) summary
    sd00017
    Location:1038 → 1060
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1036 → 1060
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1080 → 1105
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001300455.1 → NP_001287384.1  stripe, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287384.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24162, Q24163, Q8IN91
    Conserved Domains (3) summary
    sd00017
    Location:758 → 780
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:756 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:800 → 825
    zf-H2C2_2; Zinc-finger double domain

  4. NM_169786.3 → NP_732289.1  stripe, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732289.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24162, Q24163, Q8IN91
    Related
    FBpp0082967
    Conserved Domains (3) summary
    sd00017
    Location:758 → 780
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:756 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:800 → 825
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001170172.2 → NP_001163643.1  stripe, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163643.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIP0
    Conserved Domains (3) summary
    sd00017
    Location:569 → 591
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:567 → 591
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:611 → 636
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGW2 A0A0B4KGW2
E1JIP0 E1JIP0
Q24163 Q24163
Q7JP26 Q7JP26
Q8IN91 Q8IN91
Q9VED3 Q9VED3

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