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MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like [ Gallus gallus (chicken) ]

Gene ID: 421633, updated on 17-Aug-2024

Summary

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Symbol
MTHFD1Lprovided by CGNC
Full Name
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 likeprovided by CGNC
Primary source
CGNC:9427
See related
Ensembl:ENSGALG00010005610
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See MTHFD1L in Genome Data Viewer
Location:
chromosome: 3
Exon count:
32
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (48325670..48468005)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (48227744..48369905)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene iodotyrosine deiodinase Neighboring gene pleckstrin homology and RhoGEF domain containing G1 Neighboring gene uncharacterized LOC101751253 Neighboring gene A-kinase anchoring protein 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables formate-tetrahydrofolate ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
monofunctional C1-tetrahydrofolate synthase, mitochondrial
XP_004935674.2
XP_025004698.2
XP_040522291.1
XP_040522292.1
XP_040522293.1
XP_040522295.1
XP_040522296.1
XP_040553585.1
XP_040553587.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    48325670..48468005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004935617.5 → XP_004935674.2  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8V0XPZ8, A0A8V0XSP4
    Related
    ENSGALP00010007976.1, ENSGALT00010013446.1
    Conserved Domains (3) summary
    cd05212
    Location:157 → 291
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:308 → 934
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:39 → 249
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  2. XM_040697651.2 → XP_040553585.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X2

    Conserved Domains (3) summary
    cd05212
    Location:157 → 291
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PRK14191
    Location:36 → 250
    PRK14191; bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD
    PLN02759
    Location:308 → 436
    PLN02759; Formate--tetrahydrofolate ligase

  3. XM_025148930.3 → XP_025004698.2  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X4

    Conserved Domains (3) summary
    cd05212
    Location:157 → 291
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PRK14191
    Location:36 → 250
    PRK14191; bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD
    PLN02759
    Location:308 → 420
    PLN02759; Formate--tetrahydrofolate ligase

  4. XM_040697653.1 → XP_040553587.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X3

    Conserved Domains (1) summary
    PLN02759
    Location:1 → 501
    PLN02759; Formate--tetrahydrofolate ligase

RNA

  1. XR_003074319.3 RNA Sequence

  2. XR_005858257.2 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    48227744..48369905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040666357.2 → XP_040522291.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8V0XSP4
    Conserved Domains (3) summary
    cd05212
    Location:157 → 291
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:308 → 934
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:39 → 249
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  2. XM_040666358.2 → XP_040522292.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X5

    UniProtKB/TrEMBL
    A0A8V0XSP4
    Conserved Domains (3) summary
    cd05212
    Location:157 → 291
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:308 → 847
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:39 → 249
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  3. XM_040666359.2 → XP_040522293.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X2

    Conserved Domains (3) summary
    cd05212
    Location:157 → 291
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PRK14191
    Location:36 → 250
    PRK14191; bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD
    PLN02759
    Location:308 → 442
    PLN02759; Formate--tetrahydrofolate ligase

  4. XM_040666362.2 → XP_040522296.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X4

    Conserved Domains (3) summary
    cd05212
    Location:157 → 291
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PRK14191
    Location:36 → 250
    PRK14191; bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD
    PLN02759
    Location:308 → 420
    PLN02759; Formate--tetrahydrofolate ligase

  5. XM_040666361.1 → XP_040522295.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X3

    Conserved Domains (1) summary
    PLN02759
    Location:1 → 501
    PLN02759; Formate--tetrahydrofolate ligase

RNA

  1. XR_005847690.2 RNA Sequence

  2. XR_005847691.2 RNA Sequence

Nucleotide Protein
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