U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

wrd well-rounded [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42169, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
wrdprovided by FlyBase
Official Full Name
well-roundedprovided by FlyBase
Primary source
FLYBASE:FBgn0042693
Locus tag
Dmel_CG7913
See related
AllianceGenome:FB:FBgn0042693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.420; B'; B'/PR61; B56-1; BcDNA:GM05554; CG 7913; CG7901; CG7913; dB56-1; Dmel\CG7913; dPP2A; dPP2A-B56-1; i234; PP2A; PP2A B'; PP2A-B; pp2A-B'; PP2A-B'; PP2A[B'-1]; Wrd
Summary
Predicted to enable protein phosphatase activator activity. Involved in several processes, including negative regulation of signal transduction; neuromuscular synaptic transmission; and synaptonemal complex disassembly. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in embryonic/larval neuromuscular junction; larval central nervous system; and organism. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 35. Orthologous to several human genes including PPP2R5D (protein phosphatase 2 regulatory subunit B'delta). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See wrd in Genome Data Viewer
Location:
90F4-90F5; 3-62 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18167757..18180049)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13993479..14005771)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene cap binding protein 20 Neighboring gene uncharacterized protein Neighboring gene Peroxiredoxin 5 Neighboring gene cadmus Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 5 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Phosphorylation status of the SCR homeodomain determines its functional activity: essential role for protein phosphatase 2A,B'. Berry M, et al. EMBO J, 2000 Jun 15. PMID 10856239, Free PMC Article
  2. Drosophila protein phosphatases 2A B' Wdb and Wrd regulate meiotic centromere localization and function of the MEI-S332 Shugoshin. Pinto BS, et al. Proc Natl Acad Sci U S A, 2017 Dec 5. PMID 29158400, Free PMC Article
  3. PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation. Hahn K, et al. Cell Metab, 2010 May 5. PMID 20444422
  4. Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity. Sim JPL, et al. Neuromolecular Med, 2020 Jun. PMID 31664682, Free PMC Article
  5. Par-1 and PP2A: Yin-Yang of Bazooka localization. Choi KW, et al. Fly (Austin), 2007 Jul-Aug. PMID 18820442

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56.
    Title: SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56.
  2. Wdb and Wrd contribute to MEI-S332's ability to ensure accurate segregation of sister chromatids but in centromere localization, they do not act solely downstream of MEI-S332.
    Title: Drosophila protein phosphatases 2A B' Wdb and Wrd regulate meiotic centromere localization and function of the MEI-S332 Shugoshin.
  3. The metabolic defects of cycG mutant animals are abrogated by a concomitant loss of Wdb, CycG presumably influences Akt1 activity at the PP2A nexus; Well rounded (Wrd), another B' subunit of PP2A in Drosophila, binds CycG similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG mutants.
    Title: A triangular connection between Cyclin G, PP2A and Akt1 in the regulation of growth and metabolism in Drosophila.
  4. a PP2A holoenzyme containing the PP2A-B' regulatory subunit has no role in the dephosphorylation and activation of Sex comb reduced
    Title: Non-requirement of a regulatory subunit of Protein Phosphatase 2A, PP2A-B', for activation of Sex comb reduced activity in Drosophila melanogaster.
  5. Study suggests that in photoreceptors, Par-1 blocks the localization of Baz to AJ whereas protein phosphatase 2A (PP2A) promotes Baz localization by antagonizing the Par-1 effects.
    Title: Par-1 and PP2A: Yin-Yang of Bazooka localization.
  6. The results reveal that the B56-containing isoform of PP2A functions within multiple signaling pathways, including those that regulate expression of reaper and the response to oxidative stress, thus promoting cell survival in Drosophila.
    Title: A functional genomics analysis of the B56 isoforms of Drosophila protein phosphatase 2A.
  7. antagonism between PP2A and Par-1 plays a key role in Baz localization at adherens junctions in photoreceptor morphogenesis
    Title: Antagonistic functions of Par-1 kinase and protein phosphatase 2A are required for localization of Bazooka and photoreceptor morphogenesis in Drosophila.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase regulator activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in meiotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in sex comb development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptonemal complex disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
well-rounded
Names
CG7913-PA
CG7913-PB
CG7913-PC
CG7913-PD
CG7913-PE
CG7913-PI
CG7913-PJ
CG7913-PK
CG7913-PL
CG7913-PM
CG7913-PN
CG7913-PO
CG7913-PP
CG7913-PQ
PP2A B' regulatory subunit
PP2A B' subunit
PP2A-B'
protein phosphatase 2A
protein phosphatase 2A B'
protein phosphatase 2A regulatory B subunit
protein phosphatase 2A-B'
regulatory B' subunit of PP2A
well rounded
wrd-PA
wrd-PB
wrd-PC
wrd-PD
wrd-PE
wrd-PI
wrd-PJ
wrd-PK
wrd-PL
wrd-PM
wrd-PN
wrd-PO
wrd-PP
wrd-PQ

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    18167757..18180049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144598.3 → NP_001138070.1  well-rounded, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138070.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D2NUL2, Q5BIJ2
    Conserved Domains (2) summary
    PLN00122
    Location:499 → 598
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:193 → 594
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  2. NM_001144599.2 → NP_001138071.1  well-rounded, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138071.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0L6
    Conserved Domains (2) summary
    PLN00122
    Location:499 → 598
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:193 → 594
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  3. NM_142424.3 → NP_650681.2  well-rounded, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650681.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6SV32, Q0KI58
    Related
    FBpp0082975
    Conserved Domains (2) summary
    PLN00122
    Location:499 → 598
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:193 → 594
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  4. NM_169787.2 → NP_732293.1  well-rounded, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732293.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6SV32, Q0KI58
    Related
    FBpp0082974
    Conserved Domains (2) summary
    PLN00122
    Location:499 → 598
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:193 → 594
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  5. NM_001144600.2 → NP_001138072.1  well-rounded, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138072.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0L7
    Conserved Domains (2) summary
    PLN00122
    Location:267 → 366
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:1 → 362
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  6. NM_001275766.1 → NP_001262695.1  well-rounded, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262695.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHB9
    Conserved Domains (2) summary
    PLN00122
    Location:512 → 611
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:206 → 607
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  7. NM_001275765.1 → NP_001262694.1  well-rounded, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262694.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHP7, Q9NFM7
    Conserved Domains (2) summary
    PLN00122
    Location:512 → 611
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:206 → 607
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  8. NM_001260247.1 → NP_001247176.1  well-rounded, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247176.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6SV32, Q0KI58
    Conserved Domains (2) summary
    PLN00122
    Location:499 → 598
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:193 → 594
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  9. NM_001260248.1 → NP_001247177.1  well-rounded, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247177.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6SV32, Q0KI58
    Conserved Domains (2) summary
    PLN00122
    Location:499 → 598
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:193 → 594
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  10. NM_001260250.1 → NP_001247179.1  well-rounded, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247179.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D2NUL2, Q5BIJ2
    Conserved Domains (2) summary
    PLN00122
    Location:499 → 598
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:193 → 594
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  11. NM_001260249.1 → NP_001247178.1  well-rounded, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247178.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6SV32, Q0KI58
    Conserved Domains (2) summary
    PLN00122
    Location:499 → 598
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:193 → 594
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  12. NM_169788.1 → NP_732294.1  well-rounded, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732294.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6SV32, Q8IN90
    Related
    FBpp0082976, FBtr0083554
    Conserved Domains (2) summary
    PLN00122
    Location:383 → 482
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:77 → 478
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  13. NM_169789.2 → NP_732295.1  well-rounded, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732295.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IN89
    Related
    FBpp0082978
    Conserved Domains (2) summary
    PLN00122
    Location:780 → 879
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:474 → 875
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  14. NM_169790.1 → NP_732296.1  well-rounded, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732296.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEC6
    Related
    FBpp0082977, FBtr0083555
    Conserved Domains (2) summary
    PLN00122
    Location:780 → 879
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:474 → 875
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHB9 A0A0B4KHB9
A0A0B4KHP7 A0A0B4KHP7
B7Z0L6 B7Z0L6
B7Z0L7 B7Z0L7
Q0KI58 Q0KI58
Q5BIJ2 Q5BIJ2
Q8IN89 Q8IN89
Q8IN90 Q8IN90
Q95S91 Q95S91
Q9NFM7 Q9NFM7
Q9VEC6 Q9VEC6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous