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CG12321 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42174, updated on 9-Dec-2024

Summary

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Official Symbol
CG12321provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0038577
Locus tag
Dmel_CG12321
See related
AllianceGenome:FB:FBgn0038577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG12321
Summary
Predicted to be involved in proteasome assembly. Predicted to be active in cytosol and nucleus. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in proteosome-associated autoinflammatory syndrome 4. Orthologous to human PSMG2 (proteasome assembly chaperone 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG12321 in Genome Data Viewer
Location:
90F6-90F6; 3-62 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18187805..18188707, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14013527..14014429, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene well-rounded Neighboring gene cadmus Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 5 Neighboring gene Mediator complex subunit 17 Neighboring gene uncharacterized protein Neighboring gene Sequence-specific single-stranded DNA-binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a Drosophila proteasome regulatory network. Lundgren J, et al. Mol Cell Biol, 2005 Jun. PMID 15899868, Free PMC Article
  2. Wolbachia and Virus Alter the Host Transcriptome at the Interface of Nucleotide Metabolism Pathways. Lindsey ARI, et al. mBio, 2021 Feb 9. PMID 33563832, Free PMC Article
  3. Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Dunn JG, et al. Elife, 2013 Dec 3. PMID 24302569, Free PMC Article
  4. MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer. Tsuboyama N, et al. Genome Biol, 2022 Sep 30. PMID 36180891, Free PMC Article
  5. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in proteasome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG12321-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    18187805..18188707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142428.3 → NP_650685.1  uncharacterized protein Dmel_CG12321 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650685.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEC2
    Related
    FBpp0083036
    Conserved Domains (1) summary
    pfam09754
    Location:25 → 126
    PAC2; PAC2 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VEC2 Q9VEC2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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