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MED17 Mediator complex subunit 17 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42175, updated on 9-Dec-2024

Summary

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Official Symbol
MED17provided by FlyBase
Official Full Name
Mediator complex subunit 17provided by FlyBase
Primary source
FLYBASE:FBgn0038578
Locus tag
Dmel_CG7957
See related
AllianceGenome:FB:FBgn0038578
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7957; dMED17; Dmel\CG7957; dTrap80; dTRAP80; dTRAP80/SRB4; l(3)s2956; Med17; p70; Trap80; TRAP80
Summary
Enables DNA-binding transcription factor binding activity and transcription coregulator activity. Contributes to transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II and sex comb development. Located in nucleus and pericentric heterochromatin. Part of mediator complex. Is expressed in several structures, including antennal primordium; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly. Orthologous to human MED17 (mediator complex subunit 17). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See MED17 in Genome Data Viewer
Location:
90F6-90F6; 3-62 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18189072..18191265)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14014794..14016987)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sequence-specific single-stranded DNA-binding protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Efficient metal-specific transcription activation by Drosophila MTF-1 requires conserved cysteine residues in the carboxy-terminal domain. Marr SK, et al. Biochim Biophys Acta, 2012 Aug. PMID 22484022, Free PMC Article
  2. A novel genetic system for analysis of co-activators for the N-terminal transactivation function domain of the human androgen receptor. Takeyama K, et al. Biosci Biotechnol Biochem, 2004 Jun. PMID 15215582
  3. Establishment of cell fate during early Drosophila embryogenesis requires transcriptional Mediator subunit dMED31. Bosveld F, et al. Dev Biol, 2008 Jan 15. PMID 18083158
  4. Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth. Guo L, et al. Nucleic Acids Res, 2016 Sep 19. PMID 27207882, Free PMC Article
  5. Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Boube M, et al. Cell, 2002 Jul 26. PMID 12150923

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. dTRAP80 serves as a genuine activator-binding target responsible for a distinct group of activators.
    Title: Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription coregulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription initiation by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in sex comb development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
part_of mediator complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pericentric heterochromatin IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
mediator complex subunit 17
Names
CG7957-PA
MED17-PA
mediator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    18189072..18191265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142429.3 → NP_650686.1  mediator complex subunit 17 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650686.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VEC1
    Related
    FBpp0082980
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VEC1.1 Q9VEC1

Gene LinkOut

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