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MED17 - Mediator complex subunit 17

Enables DNA-binding transcription factor binding activity and transcription coregulator activity. Contributes to transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II and sex comb development. Located in nucleus and pericentric heterochromatin. Part of mediator complex. Is expressed in several structures, including antennal primordium; anterior endoderm; embryonic/larval midgut primordium; ganglia; and head epidermis primordium. Human ortholog(s) of this gene implicated in infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly. Orthologous to human MED17 (mediator complex subunit 17). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa