14-3-3epsilon 14-3-3epsilon [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: 14-3-3epsilonprovided by FlyBase
Official Full Name: 14-3-3epsilonprovided by FlyBase
Primary source: FLYBASE:FBgn0020238
Locus tag: Dmel_CG31196
See related: AllianceGenome:FB:FBgn0020238
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 14-3-3; 14-3-3 epsilon; 14-3-3-e; 14-3-3-epsilon; 14-3-30epsilon; 14-3-3e; 14-3-3EPSILON; 14-3-3omicron; 14.3.3; 14.3.3 epsilon; 1433epsilon; 143E_DROME; anon-WO0172774.141; anon-WO02059370.52; CG31196; CT24092; D14-3-3e; d14-3-3epsilon; D14-3-3epsilon; Dmel\CG31196; e-14-3-3; EK3-5; eps; Eps; l(3)j2B10; par-5; Par-5; PAR-5; PAR5; SR3-9; Su(Raf)3B
Summary: Enables several functions, including phosphoserine residue binding activity; protein heterodimerization activity; and transcription coactivator binding activity. Involved in several processes, including neuron differentiation; oocyte differentiation; and regulation of cell cycle process. Located in several cellular components, including chromosome; germline ring canal; and nucleus. Is expressed in several structures, including adult brain; adult brain cell body rind; epithelial furrow; presumptive embryonic/larval system; and synaptic neuropil domain. Orthologous to human YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 90F10-90F10; 3-62 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18242531..18250550)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14068253..14076272)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrative Role of 14-3-3epsilon in Sleep Regulation.
Title: Integrative Role of 14-3-3ε in Sleep Regulation.
Study suggests a novel mechanism of Tor regulation mediated by 14-3-3 interaction with Tctp and Rheb.
Title: 14-3-3 proteins regulate Tctp-Rheb interaction for organ growth in Drosophila.
14-3-3epsilon has a critical role in cellular metabolism involving either molecular crosstalk with the EcR or direct interaction with metabolic proteins
Title: Proteome Analysis of Drosophila Mutants Identifies a Regulatory Role for 14-3-3ε in Metabolic Pathways.
The Khc73 stalk/14-3-3/NudE pathway defines a physical connection that coordinates the activities of multiple motor proteins to precisely position the spindle.
Title: A NudE/14-3-3 pathway coordinates dynein and the kinesin Khc73 to position the mitotic spindle.
role of 14-3-3epsilon in germ cell migration
Title: 14-3-3ε Is required for germ cell migration in Drosophila.
14-3-3epsilon acts as a biochemical control point for axon guidance in Drosophila, silencing Plexin A repulsive axon guidance and regulating a semaphorin repulsion/integrin adhesion switch.
Title: 14-3-3ε couples protein kinase A to semaphorin signaling and silences plexin RasGAP-mediated axonal repulsion.
We conclude that 14-3-3epsilon is required for Rab11-positive vesicle function, which in turn enables antimicrobial peptide secretion during an innate immune response.
Title: Drosophila 14-3-3ε has a crucial role in anti-microbial peptide secretion and innate immunity.
Hpo signaling inhibited Yki nuclear localization and activity by phosphorylating Yki and both isoforms of 14-3-3, 14-3-3varepsilon and 14-3-3zeta, regulate Yki activity through modulating its subcellular localization.
Title: Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms.
Serves as a central modulator of forkhead transcription factor FoxO activity in the regulation of growth, cell death and longevity in vivo.
Title: 14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila.
Drosophila 14-3-3/PAR-5 is an essential mediator of PAR-1 function in axis formation.
Title: Drosophila 14-3-3/PAR-5 is an essential mediator of PAR-1 function in axis formation.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables molecular sequestering activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoserine residue binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoserine residue binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R8 cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic sequestering of protein	IDA Inferred from Direct Assay more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived oocyte fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule sliding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection arborization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte microtubule cytoskeleton polarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Ras protein signal transduction	HGI more info	PubMed
involved_in positive regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in wing disc dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	HDA more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in germline ring canal	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: 14-3-3epsilon

Names: 14-3-3 epsilon; 14-3-3 protein epsilon; 14-3-3&epsilon; 14-3-3epsilon-PA; 14-3-3epsilon-PB; 14-3-3epsilon-PC; 14-3-3epsilon-PD; CG31196-PA; CG31196-PB; CG31196-PC; CG31196-PD; Tyrosine-3-monooxygenase; epsilon; suppressor of Ras85D 3-9

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

18242531..18250550

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169798.3 → NP_732311.1 14-3-3epsilon, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732311.1

Status: REVIEWED

UniProtKB/TrEMBL

D3DMY5

Related

FBpp0082990

Conserved Domains (1) summary

cd10020
Location:4 → 233

14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein
NM_169797.3 → NP_732310.1 14-3-3epsilon, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732310.1

Status: REVIEWED

UniProtKB/TrEMBL

D3DMY5

Related

FBpp0082988

Conserved Domains (1) summary

cd10020
Location:4 → 233

14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein
NM_169796.2 → NP_732309.1 14-3-3epsilon, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732309.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P92177, Q8IN86, Q8IN87, Q9VEA8

UniProtKB/TrEMBL

C6TP70, D3DMY5

Related

FBpp0082987

Conserved Domains (1) summary

cd10020
Location:4 → 233

14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein
NM_169799.2 → NP_732312.1 14-3-3epsilon, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732312.1

Status: REVIEWED

UniProtKB/TrEMBL

D3DMY5

Related

FBpp0082989

Conserved Domains (1) summary

cd10020
Location:4 → 233

14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein