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CG8064 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42196, updated on 9-Dec-2024

Summary

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Official Symbol
CG8064provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0038597
Locus tag
Dmel_CG8064
See related
AllianceGenome:FB:FBgn0038597
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
DIP2; Dmel\CG8064
Summary
Predicted to enable snoRNA binding activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and hindgut proper primordium. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma. Orthologous to human WDR3 (WD repeat domain 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG8064 in Genome Data Viewer
Location:
91A1-91A1; 3-63 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18283660..18286624)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14109382..14112346)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 1A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene lethal (3) 05822 Neighboring gene Dynein light chain 90F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genetic screen identifies new regulators of steroid-triggered programmed cell death in Drosophila. Wang L, et al. Genetics, 2008 Sep. PMID 18757938, Free PMC Article
  2. Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation. Sanchez CG, et al. Cell Stem Cell, 2016 Feb 4. PMID 26669894, Free PMC Article
  3. Transcriptional response to dietary restriction in Drosophila melanogaster. Ding F, et al. J Insect Physiol, 2014 Oct. PMID 24819200, Free PMC Article
  4. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article
  5. Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Neumüller RA, et al. Cell Stem Cell, 2011 May 6. PMID 21549331, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Pwp2p-containing subcomplex of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG8064-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    18283660..18286624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142448.4 → NP_650705.1  uncharacterized protein Dmel_CG8064 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650705.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VE98
    Related
    FBpp0082995
    Conserved Domains (5) summary
    COG2319
    Location:331 → 702
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:401 → 693
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam04003
    Location:780 → 882
    Utp12; Dip2/Utp12 Family
    sd00039
    Location:408 → 441
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:60 → 511
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VE98 Q9VE98

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