WRNexo WRN exonuclease [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: WRNexoprovided by FlyBase
Official Full Name: WRN exonucleaseprovided by FlyBase
Primary source: FLYBASE:FBgn0038608
Locus tag: Dmel_CG7670
See related: AllianceGenome:FB:FBgn0038608
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7670; Dmel\CG7670; DmWRNexo; Wrnexo
Summary: Enables double-stranded DNA 3'-5' DNA exonuclease activity and single-stranded DNA 3'-5' DNA exonuclease activity. Involved in negative regulation of mitotic recombination. Located in nucleus. Is expressed in several structures, including CNS glial cell; central brain primordium; embryonic/larval midgut primordium; ganglia; and gut section. Used to study Werner syndrome. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 91A3-91A3; 3-63 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18364244..18366162, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14189966..14191884, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of Stress Responses in a Drosophila Model of Werner Syndrome.
Title: Characterization of Stress Responses in a Drosophila Model of Werner Syndrome.
WRNexo is important for recovery following both endogenous and exogenous replication stress; the critical role of WRNexo during replication stress does not depend on exonuclease activity
Title: The Drosophila Werner exonuclease participates in an exonuclease-independent response to replication stress.
DmWRNexo is a 3'-5' exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease.
Title: DmWRNexo is a 3'-5' exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease.
The Drosophila WRN ortholog demonstrates an important role for WRN exonuclease in maintaining genome stability.
Title: Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-5' exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 3'-5' exonuclease activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 3'-5' exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables double-stranded DNA 3'-5' DNA exonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA 3'-5' DNA exonuclease activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of mitotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: WRN exonuclease

Names: CG7670-PA; CG7670-PB; CG7670-PC; WRNexo-PA; WRNexo-PB; WRNexo-PC

NP_001163646.1

EC 3.1.11.1

EC 3.1.11.2

NP_001287389.1

EC 3.1.11.1

EC 3.1.11.2

NP_650715.3

EC 3.1.11.1

EC 3.1.11.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

18364244..18366162 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300460.1 → NP_001287389.1 WRN exonuclease, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287389.1

Status: REVIEWED

UniProtKB/TrEMBL

E8NH59

Conserved Domains (1) summary

cd06141
Location:141 → 313

WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
NM_142458.4 → NP_650715.3 WRN exonuclease, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650715.3

Status: REVIEWED

UniProtKB/Swiss-Prot

A7L742, B6IDR2, Q961E1, Q9VE86

Related

FBpp0083007

Conserved Domains (1) summary

cd06141
Location:141 → 313

WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
NM_001170175.2 → NP_001163646.1 WRN exonuclease, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163646.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JIP3

Conserved Domains (1) summary

cd06141
Location:142 → 314

WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins