ChT Choline transporter [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ChTprovided by FlyBase
Official Full Name: Choline transporterprovided by FlyBase
Primary source: FLYBASE:FBgn0038641
Locus tag: Dmel_CG7708
See related: AllianceGenome:FB:FBgn0038641
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7708; Dmel\CG7708; dSLC5A15
Summary: Predicted to enable amino acid transmembrane transporter activity and choline:sodium symporter activity. Predicted to be involved in acetylcholine biosynthetic process; amino acid transmembrane transport; and choline transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; embryonic head sensory system; ganglia; and sense organ. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 7; congenital myasthenic syndrome 20; and depressive disorder. Orthologous to human SLC5A7 (solute carrier family 5 member 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18680604..18686739)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14506326..14512461)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Choline Transporter regulates olfactory habituation via a neuronal triad of excitatory, inhibitory and mushroom body neurons.
Title: Choline Transporter regulates olfactory habituation via a neuronal triad of excitatory, inhibitory and mushroom body neurons.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables amino acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables choline transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables choline:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetylcholine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetylcholine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in amino acid transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in choline transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain