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Cyp12a5 Cytochrome P450 12a5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42293, updated on 9-Dec-2024

Summary

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Official Symbol
Cyp12a5provided by FlyBase
Official Full Name
Cytochrome P450 12a5provided by FlyBase
Primary source
FLYBASE:FBgn0038680
Locus tag
Dmel_CG11821
See related
AllianceGenome:FB:FBgn0038680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
12a5; CG11821; Cyp12A5; CYP12a5; CYP12A5; Dmel\CG11821
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; embryonic/larval Malpighian tubule; embryonic/larval midgut; and gastric caecum. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Cyp12a5 in Genome Data Viewer
Location:
91F2-91F3; 3-66 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19132648..19134704)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14958370..14960426)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ATP synthase, subunit D Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 12a4 Neighboring gene Phosphopantothenoylcysteine synthetase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence for activation of nitenpyram by a mitochondrial cytochrome P450 in Drosophila melanogaster. Harrop TW, et al. Pest Manag Sci, 2018 Jul. PMID 29316188
  2. Expression of Cyp6g1 and Cyp12d1 in DDT resistant and susceptible strains of Drosophila melanogaster. Festucci-Buselli RA, et al. Insect Mol Biol, 2005 Jan. PMID 15663776
  3. Gene Regulatory Variation in Drosophila melanogaster Renal Tissue. Glaser-Schmitt A, et al. Genetics, 2018 Sep. PMID 29976765, Free PMC Article
  4. Cyp12a4 confers lufenuron resistance in a natural population of Drosophila melanogaster. Bogwitz MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16120680, Free PMC Article
  5. SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation. Vorobyeva NE, et al. Cell Cycle, 2011 Jun 1. PMID 21519192

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 12a5
Names
CG11821-PA
Cyp12a5-PA
cytochrome P450
NP_650782.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19132648..19134704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142525.4 → NP_650782.1  cytochrome P450 12a5 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650782.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6SEI2, Q8MQI5, Q9VE01
    Related
    FBpp0083144
    Conserved Domains (1) summary
    pfam00067
    Location:81 → 531
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VE01.1 Q9VE01

Gene LinkOut

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