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myd mayday [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42303, updated on 4-Jan-2025

Summary

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Official Symbol
mydprovided by FlyBase
Official Full Name
maydayprovided by FlyBase
Primary source
FLYBASE:FBgn0051475
Locus tag
Dmel_CG31475
See related
AllianceGenome:FB:FBgn0051475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14281; CG31475; CG3768; Dmel\CG31475
Summary
Predicted to enable calcium ion binding activity. Involved in maintenance of synapse structure. Acts upstream of with a positive effect on retrograde trans-synaptic signaling. Is active in trans-Golgi network. Is expressed in embryonic proventriculus and embryonic proventriculus intermediate layer. Orthologous to human SDF4 (stromal cell derived factor 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See myd in Genome Data Viewer
Location:
91F11-91F11; 3-66 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19180659..19201096)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15006381..15026818)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46039 Neighboring gene long non-coding RNA:CR46393 Neighboring gene cryptochrome Neighboring gene vibrator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age. Sidisky JM, et al. Elife, 2021 Mar 5. PMID 33667157, Free PMC Article
  2. Molecular logic of synaptic diversity between Drosophila tonic and phasic motoneurons. Jetti SK, et al. Neuron, 2023 Nov 15. PMID 37611584
  3. Genome-Wide Association Study on Male Genital Shape and Size in Drosophila melanogaster. Takahara B, et al. PLoS One, 2015. PMID 26182199, Free PMC Article
  4. NDR kinase tricornered genetically interacts with Ccm3 and metabolic enzymes in Drosophila melanogaster tracheal development. Hudson J, et al. G3 (Bethesda), 2023 Mar 9. PMID 36653023, Free PMC Article
  5. A Hopscotch-chromatin connection. Betz A, et al. Nat Genet, 2006 Sep. PMID 16941005

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age.
    Title: Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

mobile_element

  • Loc: 19193036-19197275 mobile_element_type = transposon:F{}1387

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium-ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of synapse structure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_positive_effect retrograde trans-synaptic signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mayday
Names
CG31475-PA
CG31475-PB
myd-PA
myd-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19180659..19201096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169851.2 → NP_732406.1  mayday, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732406.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95T97, Q9VDY9
    Related
    FBpp0083149
    Conserved Domains (2) summary
    pfam13499
    Location:160 → 224
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:344 → 398
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. NM_001275796.1 → NP_001262725.1  mayday, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262725.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95T97, Q9VDY9
    Conserved Domains (2) summary
    pfam13499
    Location:160 → 224
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:344 → 398
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VDY9 Q9VDY9

Gene LinkOut

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