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Polr2M RNA polymerase II subunit M [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42309, updated on 4-Jan-2025

Summary

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Official Symbol
Polr2Mprovided by FlyBase
Official Full Name
RNA polymerase II subunit Mprovided by FlyBase
Primary source
FLYBASE:FBgn0038692
Locus tag
Dmel_CG3773
See related
AllianceGenome:FB:FBgn0038692
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:fe2D10; anon-EST:fe2D12; CG3773; Dmel\CG3773; Gdn1; Gdown1
Summary
Predicted to enable transcription elongation factor activity. Predicted to be involved in transcription elongation by RNA polymerase II. Part of RNA polymerase II, core complex. Orthologous to human POLR2M (RNA polymerase II subunit M). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Polr2M in Genome Data Viewer
Location:
91F12-91F12; 3-66 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19229463..19230832)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15055185..15056554)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncoordinated 79 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1. Jishage M, et al. Nat Struct Mol Biol, 2018 Sep. PMID 30190596, Free PMC Article
  2. RNA polymerase II pausing during development. Gaertner B, et al. Development, 2014 Mar. PMID 24595285, Free PMC Article
  3. Dominant suppressor genes of p53-induced apoptosis in Drosophila melanogaster. Szlanka T, et al. G3 (Bethesda), 2024 Sep 4. PMID 38985658, Free PMC Article
  4. In silico identification of Drosophila melanogaster genes encoding RNA polymerase subunits. Marygold SJ, et al. MicroPubl Biol, 2020 Oct 20. PMID 33274328, Free PMC Article
  5. A screen for fast evolving genes from Drosophila. Schmid KJ, et al. Proc Natl Acad Sci U S A, 1997 Sep 2. PMID 9275195, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transcription elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II, core complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA polymerase II subunit M
Names
CG3773-PA
Gdown1
Polr2M-PA
anon-fast-evolving-2D10
anon-fast-evolving-2D12

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19229463..19230832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142537.2 → NP_650794.1  RNA polymerase II subunit M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650794.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0PTU7, Q9VDY6
    Related
    FBpp0083151
    Conserved Domains (1) summary
    pfam15328
    Location:39 → 233
    GCOM2; Putative GRINL1B complex locus protein 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MQV7 Q8MQV7
Q9VDY6 Q9VDY6

Gene LinkOut

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