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Naam Nicotinamide amidase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42348, updated on 4-Jan-2025

Summary

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Official Symbol
Naamprovided by FlyBase
Official Full Name
Nicotinamide amidaseprovided by FlyBase
Primary source
FLYBASE:FBgn0051216
Locus tag
Dmel_CG31216
See related
AllianceGenome:FB:FBgn0051216
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAM52663; anon-WO0172774.59; anon-WO0172774.60; CG31216; CG7444; CG7500; D-NAAM; Dmel\CG31216; dNaam
Summary
Enables nicotinamidase activity. Involved in determination of adult lifespan; negative regulation of neuron apoptotic process; and response to oxidative stress. Is expressed in several structures, including embryonic head sensory system; scolopale cell; and sensory nervous system primordium. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Naam in Genome Data Viewer
Location:
92A13-92B1; 3-66 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19671450..19698742)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15497172..15524464)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Valine-CAC 2-5 Neighboring gene ora transientless Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutamate-gated chloride channel subunit alpha Neighboring gene long non-coding RNA:CR43488

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tripeptide IRW Upregulates NAMPT Protein Levels in Cells and Obese C57BL/6J Mice. Bhullar KS, et al. J Agric Food Chem, 2021 Feb 10. PMID 33522796
  2. Life span extension and neuronal cell protection by Drosophila nicotinamidase. Balan V, et al. J Biol Chem, 2008 Oct 10. PMID 18678867, Free PMC Article
  3. Reconstructing eukaryotic NAD metabolism. Rongvaux A, et al. Bioessays, 2003 Jul. PMID 12815723
  4. The NAD(+) precursor NMN activates dSarm to trigger axon degeneration in Drosophila. Llobet Rosell A, et al. Elife, 2022 Dec 23. PMID 36476387, Free PMC Article
  5. An insecticide target in mechanoreceptor neurons. Qiao X, et al. Sci Adv, 2022 Nov 25. PMID 36417522, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nicotinamidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in NAD salvage TAS
Traceable Author Statement
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
nicotinamide amidase
Names
CG31216-PA
CG31216-PB
Naam-PA
Naam-PB
nicotinamidase
NP_001262738.1
NP_732446.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19671450..19698742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169872.2 → NP_732446.1  nicotinamide amidase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732446.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VDU7
    Related
    FBpp0083200
    Conserved Domains (3) summary
    cd00051
    Location:20 → 81
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd01011
    Location:97 → 315
    nicotinamidase; Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is ...
    pfam13499
    Location:21 → 82
    EF-hand_7; EF-hand domain pair

  2. NM_001275809.1 → NP_001262738.1  nicotinamide amidase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262738.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VDU7
    Conserved Domains (3) summary
    cd00051
    Location:20 → 81
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd01011
    Location:97 → 315
    nicotinamidase; Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is ...
    pfam13499
    Location:21 → 82
    EF-hand_7; EF-hand domain pair
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VDU7 Q9VDU7

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