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MICU3 Mitochondrial calcium uptake 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42357, updated on 9-Dec-2024

Summary

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Official Symbol
MICU3provided by FlyBase
Official Full Name
Mitochondrial calcium uptake 3provided by FlyBase
Primary source
FLYBASE:FBgn0038735
Locus tag
Dmel_CG4662
See related
AllianceGenome:FB:FBgn0038735
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4662; Dmel\CG4662; micu3
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Predicted to be part of uniplex complex. Is expressed in adult head. Orthologous to several human genes including MICU3 (mitochondrial calcium uptake family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See MICU3 in Genome Data Viewer
Location:
92B3-92B3; 3-67 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19847311..19854403)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15673033..15680125)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Threonine-AGT 1-7 Neighboring gene branchless Neighboring gene uncharacterized protein Neighboring gene Inositol-requiring enzyme-1 Neighboring gene uncharacterized protein Neighboring gene Mitochondrial rRNA methyltransferase 2 Neighboring gene uncharacterized protein Neighboring gene Multidrug resistance protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comprehensive Genetic Characterization of Mitochondrial Ca(2+) Uniporter Components Reveals Their Different Physiological Requirements In Vivo. Tufi R, et al. Cell Rep, 2019 Apr 30. PMID 31042479, Free PMC Article
  2. Functionally Validating Evolutionary Conserved Risk Genes for Parkinson's Disease in Drosophila melanogaster. Baisgaard AE, et al. Insects, 2023 Feb 9. PMID 36835737, Free PMC Article
  3. Sex-specific splicing in Drosophila: widespread occurrence, tissue specificity and evolutionary conservation. Telonis-Scott M, et al. Genetics, 2009 Feb. PMID 19015538, Free PMC Article
  4. Milton assembles large mitochondrial clusters, mitoballs, to sustain spermatogenesis. Li AYZ, et al. Proc Natl Acad Sci U S A, 2023 Aug 22. PMID 37579146, Free PMC Article
  5. Sex-specific expression of alternative transcripts in Drosophila. McIntyre LM, et al. Genome Biol, 2006. PMID 16934145, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MICU3 mutants are viable with mild neurological impairment.
    Title: Comprehensive Genetic Characterization of Mitochondrial Ca(2+) Uniporter Components Reveals Their Different Physiological Requirements In Vivo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium channel regulator activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium import into the mitochondrion TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitochondrial calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of uniplex complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of uniplex complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial calcium uptake 3
Names
CG4662-PA
CG4662-PB
CG4662-PC
CG4662-PD
CG4662-PE
CG4662-PF
MICU3-PA
MICU3-PB
MICU3-PC
MICU3-PD
MICU3-PE
MICU3-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19847311..19854403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169877.2 → NP_732455.1  mitochondrial calcium uptake 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732455.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86PE4, Q8IN65
    Related
    FBpp0083224
    Conserved Domains (3) summary
    pfam13499
    Location:394 → 443
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:397 → 446
    EF-hand_8; EF-hand domain pair
    cl08302
    Location:192 → 256
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. NM_001275814.1 → NP_001262743.1  mitochondrial calcium uptake 3, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262743.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGC9, Q86PE4
    Conserved Domains (2) summary
    pfam13499
    Location:420 → 469
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:423 → 472
    EF-hand_8; EF-hand domain pair

  3. NM_001170186.2 → NP_001163657.1  mitochondrial calcium uptake 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163657.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIQ4, Q86PE4
    Conserved Domains (3) summary
    PTZ00183
    Location:193 → 305
    PTZ00183; centrin; Provisional
    pfam13499
    Location:391 → 440
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:394 → 443
    EF-hand_8; EF-hand domain pair

  4. NM_001275812.1 → NP_001262741.1  mitochondrial calcium uptake 3, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262741.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHF1, Q86PE4
    Conserved Domains (2) summary
    pfam13499
    Location:421 → 470
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:424 → 473
    EF-hand_8; EF-hand domain pair

  5. NM_001275813.1 → NP_001262742.1  mitochondrial calcium uptake 3, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262742.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGH7, Q86PE4
    Conserved Domains (3) summary
    PTZ00183
    Location:193 → 305
    PTZ00183; centrin; Provisional
    pfam13499
    Location:391 → 440
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:394 → 443
    EF-hand_8; EF-hand domain pair

  6. NM_142576.4 → NP_650833.1  mitochondrial calcium uptake 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650833.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86PE4, Q95TU0, Q9VDT8
    Related
    FBpp0083223
    Conserved Domains (3) summary
    pfam13499
    Location:394 → 443
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:397 → 446
    EF-hand_8; EF-hand domain pair
    cl08302
    Location:192 → 256
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGC9 A0A0B4KGC9
A0A0B4KGH7 A0A0B4KGH7
A0A0B4KHF1 A0A0B4KHF1
E1JIQ4 E1JIQ4
Q86PE4 Q86PE4
Q8IN65 Q8IN65
Q9VDT8 Q9VDT8

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