Ire1 - Inositol-requiring enzyme-1

Enables RNA endonuclease activity. Involved in several processes, including IRE1-mediated unfolded protein response; regulation of gene expression; and rhabdomere morphogenesis. Predicted to be part of IRE1-TRAF2-ASK1 complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to several human genes including ERN2 (endoplasmic reticulum to nucleus signaling 2). [provided by Alliance of Genome Resources, Dec 2024]

NCBI Orthologs

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