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CG4733 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42368, updated on 9-Dec-2024

Summary

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Official Symbol
CG4733provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0038744
Locus tag
Dmel_CG4733
See related
AllianceGenome:FB:FBgn0038744
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
B''; Dmel\CG4733; dPP2A-PR72; dPR72; PP2A like; PP2A-B''; PR-72; pr72; PR72
Summary
Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex. Orthologous to several human genes including PPP2R3B (protein phosphatase 2 regulatory subunit B''beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG4733 in Genome Data Viewer
Location:
92B4-92B6; 3-67 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19890689..19898738)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15716411..15724460)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Apoptotic signal-regulating kinase 1 Neighboring gene neither inactivation nor afterpotential E Neighboring gene Caseinolytic protease chaperone subunit Neighboring gene Rho GTPase activating protein at 92B Neighboring gene long non-coding RNA:CR45047 Neighboring gene Surfeit 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bidirectional regulation of fragile X mental retardation protein phosphorylation controls rhodopsin homoeostasis. Wang X, et al. J Mol Cell Biol, 2017 Apr 1. PMID 27702760
  2. A functional genomics analysis of the B56 isoforms of Drosophila protein phosphatase 2A. Liu W, et al. Mol Cell Proteomics, 2007 Feb. PMID 17121811
  3. The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification. Brownlee CW, et al. J Cell Biol, 2011 Oct 17. PMID 21987638, Free PMC Article
  4. Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase. Bielinski VA, et al. Exp Cell Res, 2007 Aug 15. PMID 17570358, Free PMC Article
  5. PP2A-twins is antagonized by greatwall and collaborates with polo for cell cycle progression and centrosome attachment to nuclei in drosophila embryos. Wang P, et al. PLoS Genet, 2011 Aug. PMID 21852958, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4733-PB
CG4733-PC
CG4733-PD
CG4733-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19890689..19898738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260269.2 → NP_001247198.1  uncharacterized protein Dmel_CG4733, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247198.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D8FT13, Q0IGX7, Q9I7J1
    Conserved Domains (1) summary
    pfam13499
    Location:690 → 791
    EF-hand_7; EF-hand domain pair

  2. NM_001300483.1 → NP_001287412.1  uncharacterized protein Dmel_CG4733, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287412.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHF0, Q0IGX7
    Conserved Domains (1) summary
    pfam13499
    Location:684 → 785
    EF-hand_7; EF-hand domain pair

  3. NM_001260268.1 → NP_001247197.1  uncharacterized protein Dmel_CG4733, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247197.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D8FT13, Q0IGX7, Q9I7J1
    Conserved Domains (1) summary
    pfam13499
    Location:690 → 791
    EF-hand_7; EF-hand domain pair

  4. NM_142585.3 → NP_650842.2  uncharacterized protein Dmel_CG4733, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650842.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D8FT13, Q0IGX7, Q9I7J1
    Conserved Domains (1) summary
    pfam13499
    Location:690 → 791
    EF-hand_7; EF-hand domain pair
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LHF0 A0A0B4LHF0
Q9I7J1 Q9I7J1

Gene LinkOut

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