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ClpX Caseinolytic protease chaperone subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42369, updated on 4-Jan-2025

Summary

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Official Symbol
ClpXprovided by FlyBase
Official Full Name
Caseinolytic protease chaperone subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0038745
Locus tag
Dmel_CG4538
See related
AllianceGenome:FB:FBgn0038745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4538; Clpx; Dmel\CG4538
Summary
Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in proteolysis involved in protein catabolic process and regulation of mitochondrial gene expression. Part of mitochondrial endopeptidase Clp complex. Is expressed in adult heart; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in erythropoietic protoporphyria. Orthologous to human CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit X). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See ClpX in Genome Data Viewer
Location:
92B4-92B6; 3-67 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19897372..19903689, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15723094..15729411, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Apoptotic signal-regulating kinase 1 Neighboring gene neither inactivation nor afterpotential E Neighboring gene uncharacterized protein Neighboring gene Rho GTPase activating protein at 92B Neighboring gene long non-coding RNA:CR45047 Neighboring gene Surfeit 6 Neighboring gene long non-coding RNA:CR45048

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A bidirectional relationship between sleep and oxidative stress in Drosophila. Hill VM, et al. PLoS Biol, 2018 Jul. PMID 30001323, Free PMC Article
  2. PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix. Thomas RE, et al. PLoS Genet, 2014. PMID 24874806, Free PMC Article
  3. Drosophila protease ClpXP specifically degrades DmLRPPRC1 controlling mitochondrial mRNA and translation. Matsushima Y, et al. Sci Rep, 2017 Aug 16. PMID 28814717, Free PMC Article
  4. Muscle mitohormesis promotes longevity via systemic repression of insulin signaling. Owusu-Ansah E, et al. Cell, 2013 Oct 24. PMID 24243023, Free PMC Article
  5. Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration. Yoon WH, et al. Neuron, 2017 Jan 4. PMID 28017472, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial protein quality control TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis involved in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrial gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of mitochondrial endopeptidase Clp complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
caseinolytic protease chaperone subunit
Names
CG4538-PA
CG4538-PC
CG4538-PD
ClpX-PA
ClpX-PC
ClpX-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19897372..19903689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300484.1 → NP_001287413.1  caseinolytic protease chaperone subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287413.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LID7
    Conserved Domains (3) summary
    smart01086
    Location:544 → 631
    ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
    COG1219
    Location:140 → 638
    ClpX; ATP-dependent protease Clp, ATPase subunit [Posttranslational modification, protein turnover, chaperones]
    pfam07724
    Location:327 → 537
    AAA_2; AAA domain (Cdc48 subfamily)

  2. NM_169880.2 → NP_732463.2  caseinolytic protease chaperone subunit, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732463.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IN64, Q9VDS7
    Conserved Domains (3) summary
    smart01086
    Location:544 → 631
    ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
    COG1219
    Location:140 → 638
    ClpX; ATP-dependent protease Clp, ATPase subunit [Posttranslational modification, protein turnover, chaperones]
    pfam07724
    Location:327 → 537
    AAA_2; AAA domain (Cdc48 subfamily)

  3. NM_142586.2 → NP_650843.1  caseinolytic protease chaperone subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650843.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IN64, Q9VDS7
    Related
    FBpp0083264
    Conserved Domains (3) summary
    smart01086
    Location:544 → 631
    ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
    COG1219
    Location:140 → 638
    ClpX; ATP-dependent protease Clp, ATPase subunit [Posttranslational modification, protein turnover, chaperones]
    pfam07724
    Location:327 → 537
    AAA_2; AAA domain (Cdc48 subfamily)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LID7 A0A0B4LID7
Q960M5 Q960M5
Q9VDS7 Q9VDS7

Gene LinkOut

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