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Xport-A exit protein of rhodopsin and TRP A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42373, updated on 9-Dec-2024

Summary

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Official Symbol
Xport-Aprovided by FlyBase
Official Full Name
exit protein of rhodopsin and TRP Aprovided by FlyBase
Primary source
FLYBASE:FBgn0038749
Locus tag
Dmel_CG4468
See related
AllianceGenome:FB:FBgn0038749
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4468; Dmel\CG4468; xport; Xport; xport-A; XPORT-A; XportA
Summary
Enables protein folding chaperone and protein transporter activity. Involved in several processes, including protein localization to membrane; protein localization to rhabdomere; and rhodopsin biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in Bolwig organ; adult head; eye photoreceptor cell; and ocellus. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Xport-A in Genome Data Viewer
Location:
92B6-92B6; 3-67 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19914396..19915412, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15740118..15741134, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein at 92B Neighboring gene long non-coding RNA:CR45047 Neighboring gene long non-coding RNA:CR45048 Neighboring gene exit protein of rhodopsin and TRP B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Xport-A functions as a chaperone by stabilizing the first five transmembrane domains of rhodopsin-1. Gaspar CJ, et al. iScience, 2023 Dec 15. PMID 38025784, Free PMC Article
  2. TRP and Rhodopsin Transport Depends on Dual XPORT ER Chaperones Encoded by an Operon. Chen Z, et al. Cell Rep, 2015 Oct 20. PMID 26456832, Free PMC Article
  3. XPORT-dependent transport of TRP and rhodopsin. Rosenbaum EE, et al. Neuron, 2011 Nov 17. PMID 22099462, Free PMC Article
  4. The Cdc42-selective GAP rich regulates postsynaptic development and retrograde BMP transsynaptic signaling. Nahm M, et al. J Cell Biol, 2010 Nov 1. PMID 21041451, Free PMC Article
  5. Analysis of insect nuclear small heat shock proteins and interacting proteins. Moutaoufik MT, et al. Cell Stress Chaperones, 2021 Jan. PMID 32888179, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel.
    Title: EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein folding chaperone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to rhabdomere IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rhodopsin biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
exit protein of rhodopsin and TRP A
Names
CG4468-PA
CPuORF of FBgn0260234
Xport-A-PA
exit protein of rhodopsin and TRP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19914396..19915412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142589.3 → NP_650846.1  exit protein of rhodopsin and TRP A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650846.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VDS3
    Related
    FBpp0083261
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VDS3 Q9VDS3

Gene LinkOut

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