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Ir92a Ionotropic receptor 92a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42415, updated on 4-Jan-2025

Summary

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Official Symbol
Ir92aprovided by FlyBase
Official Full Name
Ionotropic receptor 92aprovided by FlyBase
Primary source
FLYBASE:FBgn0038789
Locus tag
Dmel_CG15685
See related
AllianceGenome:FB:FBgn0038789
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
92a; CG15685; DmelIR92a; Dmel\CG15685; IR92a
Summary
Enables extracellular ammonia-gated monoatomic ion channel activity and olfactory receptor activity. Involved in several processes, including cellular response to ammonium ion; detection of chemical stimulus involved in sensory perception of smell; and positive regulation of calcium-mediated signaling. Predicted to be located in membrane. Is expressed in antennal coeloconic sensillum ac1; antennal lobe glomerulus VM1; and chemosensory neurons. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ir92a in Genome Data Viewer
Location:
92E4-92E4; 3-68 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20338973..20343902)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16164695..16169624)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45800 Neighboring gene uncharacterized protein Neighboring gene Sirtuin 2 Neighboring gene long non-coding RNA:CR45023 Neighboring gene Metallothionein C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Signaling Mode of the Broad-Spectrum Conserved CO(2) Receptor Is One of the Important Determinants of Odor Valence in Drosophila. MacWilliam D, et al. Neuron, 2018 Mar 7. PMID 29429938, Free PMC Article
  2. Dedicated olfactory neurons mediating attraction behavior to ammonia and amines in Drosophila. Min S, et al. Proc Natl Acad Sci U S A, 2013 Apr 2. PMID 23509267, Free PMC Article
  3. Cool and warm ionotropic receptors control multiple thermotaxes in Drosophila larvae. Omelchenko AA, et al. Front Mol Neurosci, 2022. PMID 36452407, Free PMC Article
  4. Olfactory coding in the insect brain: data and conjectures. Galizia CG. Eur J Neurosci, 2014 Jun. PMID 24698302, Free PMC Article
  5. An ammonium transporter is a non-canonical olfactory receptor for ammonia. Vulpe A, et al. Curr Biol, 2021 Aug 9. PMID 34111404, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 20343359-20343425 mobile_element_type = transposon:INE-1{}5795

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables extracellular ammonia-gated monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables olfactory receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to amine stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to ammonium ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception of smell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
ionotropic receptor 92a
Names
CG15685-PC
Ir92a-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20338973..20343902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104375.2 → NP_001097845.2  ionotropic receptor 92a [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097845.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VDN3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VDN3 Q9VDN3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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