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PTPN4 protein tyrosine phosphatase, non-receptor type 4 [ Gallus gallus (chicken) ]

Gene ID: 424234, updated on 3-Dec-2024

Summary

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Symbol
PTPN4provided by CGNC
Full Name
protein tyrosine phosphatase, non-receptor type 4provided by CGNC
Primary source
CGNC:8814
See related
Ensembl:ENSGALG00010018829
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See PTPN4 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
31
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (24941664..25042617)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (24859781..24962214)

Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 177 Neighboring gene uncharacterized LOC121111254 Neighboring gene uncharacterized LOC112532782 Neighboring gene erythrocyte membrane protein band 4.1 like 5 Neighboring gene rab9 effector protein with kelch motifs-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 4
Names
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
XP_040532951.2
XP_040532952.1
XP_040532953.1
XP_040560249.2
XP_040560250.1
XP_040560251.1
XP_046777847.1
XP_046799831.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    24941664..25042617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040704316.2 → XP_040560250.1  tyrosine-protein phosphatase non-receptor type 4 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Z7H3, A0A8V0Z848
    Related
    ENSGALP00010027142.1, ENSGALT00010045492.1
    Conserved Domains (5) summary
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00992
    Location:518 → 605
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 310
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam08736
    Location:323 → 365
    FA; FERM adjacent (FA)
    cl28904
    Location:644 → 917
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_046943875.1 → XP_046799831.1  tyrosine-protein phosphatase non-receptor type 4 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z7H3, A0A8V0Z920
    Related
    ENSGALP00010027126.1, ENSGALT00010045470.1

  3. XM_040704317.1 → XP_040560251.1  tyrosine-protein phosphatase non-receptor type 4 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Z7H3, A0A8V0Z848
    Related
    ENSGALP00010027120.1, ENSGALT00010045458.1
    Conserved Domains (5) summary
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00992
    Location:518 → 605
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 310
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam08736
    Location:323 → 365
    FA; FERM adjacent (FA)
    cl28904
    Location:644 → 917
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. XM_040704315.2 → XP_040560249.2  tyrosine-protein phosphatase non-receptor type 4 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z7H3

RNA

  1. XR_005861723.2 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    24859781..24962214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040677018.2 → XP_040532952.1  tyrosine-protein phosphatase non-receptor type 4 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Z7H3, A0A8V0Z848
    Conserved Domains (5) summary
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00992
    Location:518 → 605
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 310
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam08736
    Location:323 → 365
    FA; FERM adjacent (FA)
    cl28904
    Location:644 → 917
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_046921891.1 → XP_046777847.1  tyrosine-protein phosphatase non-receptor type 4 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z7H3, A0A8V0Z920

  3. XM_040677019.1 → XP_040532953.1  tyrosine-protein phosphatase non-receptor type 4 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Z7H3, A0A8V0Z848
    Conserved Domains (5) summary
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00992
    Location:518 → 605
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 310
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam08736
    Location:323 → 365
    FA; FERM adjacent (FA)
    cl28904
    Location:644 → 917
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. XM_040677017.2 → XP_040532951.2  tyrosine-protein phosphatase non-receptor type 4 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z7H3

RNA

  1. XR_005852021.2 RNA Sequence

Nucleotide Protein
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