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CG15923 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42443, updated on 9-Dec-2024

Summary

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Official Symbol
CG15923provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0038814
Locus tag
Dmel_CG15923
See related
AllianceGenome:FB:FBgn0038814
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG15923
Summary
Predicted to be involved in cilium assembly. Predicted to be part of MKS complex. Predicted to be active in ciliary transition zone. Is expressed in adult brain. Human ortholog(s) of this gene implicated in several diseases, including Bardet-Biedl syndrome (multiple); COACH syndrome; Joubert syndrome 6; Meckel syndrome 3; and nephronophthisis (multiple). Orthologous to human TMEM67 (transmembrane protein 67). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG15923 in Genome Data Viewer
Location:
92F3-92F3; 3-69 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20611251..20616901, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16436973..16442623, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Signal recognition particle 72 Neighboring gene Pseudouridine synthase 1 Neighboring gene bonus Neighboring gene transfer RNA:Leucine-TAA 1-1 Neighboring gene uncharacterized protein Neighboring gene Hairless

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lrrk regulates the dynamic profile of dendritic Golgi outposts through the golgin Lava lamp. Lin CH, et al. J Cell Biol, 2015 Aug 3. PMID 26216903, Free PMC Article
  2. A migrating ciliary gate compartmentalizes the site of axoneme assembly in Drosophila spermatids. Basiri ML, et al. Curr Biol, 2014 Nov 17. PMID 25447994, Free PMC Article
  3. Components of Intraflagellar Transport Complex A Function Independently of the Cilium to Regulate Canonical Wnt Signaling in Drosophila. Balmer S, et al. Dev Cell, 2015 Sep 28. PMID 26364750, Free PMC Article
  4. A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis. Pandey V, et al. Front Cell Neurosci, 2013. PMID 24058333, Free PMC Article
  5. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Dutta D, et al. Proc Natl Acad Sci U S A, 2024 Feb 27. PMID 38381787, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of MKS complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG15923-PB
CG15923-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20611251..20616901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104376.3 → NP_001097846.1  uncharacterized protein Dmel_CG15923, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097846.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NN50, Q9VDK3
    Conserved Domains (1) summary
    pfam09773
    Location:173 → 967
    Meckelin; Meckelin (Transmembrane protein 67)

  2. NM_001275840.1 → NP_001262769.1  uncharacterized protein Dmel_CG15923, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262769.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGJ7
    Conserved Domains (1) summary
    pfam09773
    Location:173 → 967
    Meckelin; Meckelin (Transmembrane protein 67)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGJ7 A0A0B4KGJ7
Q9VDK3 Q9VDK3

Gene LinkOut

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