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Lrrk - Leucine-rich repeat kinase

Enables protein serine/threonine kinase activity and small GTPase binding activity. Involved in several processes, including establishment of Golgi localization; regulation of organelle organization; and regulation of synapse organization. Located in several cellular components, including bounding membrane of organelle; dendritic tree; and subsynaptic reticulum. Is expressed in spermatozoon. Used to study Parkinson's disease; Parkinson's disease 8; and late onset Parkinson's disease. Human ortholog(s) of this gene implicated in osteosclerotic metaphyseal dysplasia. Orthologous to human LRRK1 (leucine rich repeat kinase 1). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa