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Nep4 - Neprilysin 4

Enables endopeptidase activity. Involved in proteolysis. Located in extracellular space and sarcoplasmic reticulum. Is expressed in several structures, including brain; glial cell; male germline cell; somatic muscle cell; and visceral mesoderm derivative. Used to study heart conduction disease. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2T; X-linked dominant hypophosphatemic rickets; cerebral amyloid angiopathy; membranous glomerulonephritis; and neurodegenerative disease (multiple). Orthologous to several human genes including MME (membrane metalloendopeptidase) and MMEL1 (membrane metalloendopeptidase like 1). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to Nep4

NCBI Orthologs

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Species Gene Architecture aa