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Grik grik [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42476, updated on 4-Jan-2025

Summary

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Official Symbol
Grikprovided by FlyBase
Official Full Name
grikprovided by FlyBase
Primary source
FLYBASE:FBgn0038840
Locus tag
Dmel_CG5621
See related
AllianceGenome:FB:FBgn0038840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0138359.5; CG5621; CT17756; DKaiRIC; DmelCG5621; Dmel\CG5621; KaiR1C
Summary
Predicted to enable kainate selective glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and regulation of synaptic activity. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Is expressed in adult CNS glial cell; adult brain; adult head; and transmedullary neuron Tm5c. Orthologous to human GRIK4 (glutamate ionotropic receptor kainate type subunit 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Grik in Genome Data Viewer
Location:
93A2-93A3; 3-69 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20901956..20908263)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16727678..16733985)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44947 Neighboring gene Kctd12-like Neighboring gene ncRNA Neighboring gene Turandot X Neighboring gene antisense RNA:CR44106 Neighboring gene uncharacterized protein Neighboring gene hadley

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An essential Drosophila glutamate receptor subunit that functions in both central neuropil and neuromuscular junction. Featherstone DE, et al. J Neurosci, 2005 Mar 23. PMID 15788777, Free PMC Article
  2. Novel Functional Properties of Drosophila CNS Glutamate Receptors. Li Y, et al. Neuron, 2016 Dec 7. PMID 27889096, Free PMC Article
  3. A hard-wired glutamatergic circuit pools and relays UV signals to mediate spectral preference in Drosophila. Karuppudurai T, et al. Neuron, 2014 Feb 5. PMID 24507194, Free PMC Article
  4. Autocrine inhibition by a glutamate-gated chloride channel mediates presynaptic homeostatic depression. Li X, et al. Sci Adv, 2021 Dec 3. PMID 34851664, Free PMC Article
  5. Ih channels control feedback regulation from amacrine cells to photoreceptors. Hu W, et al. PLoS Biol, 2015 Apr. PMID 25831426, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kainate selective glutamate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
grik
Names
CG5621-PA
CG5621-PC
CG5621-PD
Grik-PA
Grik-PC
Grik-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20901956..20908263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142670.3 → NP_650927.1  grik, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650927.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961Q6, Q9VDH2
    Related
    FBpp0083382
    Conserved Domains (4) summary
    cd06382
    Location:37 → 391
    PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
    pfam00060
    Location:543 → 799
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:53 → 374
    ANF_receptor; Receptor family ligand binding region
    cl21456
    Location:411 → 781
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

  2. NM_001275859.1 → NP_001262788.1  grik, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262788.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHJ0
    Conserved Domains (4) summary
    cd06382
    Location:37 → 391
    PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
    pfam00060
    Location:543 → 816
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:53 → 374
    ANF_receptor; Receptor family ligand binding region
    cl21456
    Location:411 → 781
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

  3. NM_001043270.2 → NP_001036735.2  grik, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036735.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KI38
    Conserved Domains (4) summary
    cd06382
    Location:37 → 391
    PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
    pfam00060
    Location:543 → 815
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:53 → 374
    ANF_receptor; Receptor family ligand binding region
    cl21456
    Location:411 → 781
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHJ0 A0A0B4KHJ0
Q0KI38 Q0KI38
Q9VDH2 Q9VDH2

Gene LinkOut

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