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ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [ Gallus gallus (chicken) ]

Gene ID: 424895, updated on 3-Dec-2024

Summary

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Symbol
ACAP2provided by CGNC
Full Name
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2provided by CGNC
Primary source
CGNC:52279
See related
Ensembl:ENSGALG00010017500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
CENTB2; centaurin-beta-2
Orthologs
human mouse all
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Genomic context

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See ACAP2 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
27
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (12378279..12434942)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (12181096..12237791)

Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein D Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 2 Neighboring gene xyloside xylosyltransferase 1 Neighboring gene uncharacterized LOC107054105

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap. Galan JA, et al. J Am Soc Mass Spectrom, 2011 Feb. PMID 21472591, Free PMC Article
  2. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
Names
centaurin, beta 2
cnt-b2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006548.2 → NP_001006548.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001006548.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000240
    UniProtKB/Swiss-Prot
    Q5ZK62
    UniProtKB/TrEMBL
    A0A8V0Z2Y7
    Related
    ENSGALP00010024806.1, ENSGALT00010042316.1
    Conserved Domains (7) summary
    cd07638
    Location:18 → 217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    cd00204
    Location:610 → 728
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:269 → 365
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:267 → 361
    PH; PH domain
    pfam01412
    Location:399 → 517
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:612 → 706
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:610 → 638
    ANK; ANK repeat [structural motif]

  2. NM_001396171.1 → NP_001383100.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000240
    UniProtKB/TrEMBL
    A0A8V0Z2Y7
    Related
    ENSGALP00010024825.1, ENSGALT00010042335.1
    Conserved Domains (5) summary
    PTZ00322
    Location:651 → 735
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd07638
    Location:18 → 217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    cd13250
    Location:269 → 372
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:617 → 645
    ANK; ANK repeat [structural motif]
    cd08851
    Location:406 → 521
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    12378279..12434942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040705559.2 → XP_040561493.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q2U396
    Conserved Domains (6) summary
    PTZ00322
    Location:694 → 778
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd07638
    Location:22 → 221
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    COG5347
    Location:417 → 649
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    cd13250
    Location:277 → 380
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:660 → 688
    ANK; ANK repeat [structural motif]
    cd08851
    Location:414 → 529
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

  2. XM_040705563.2 → XP_040561497.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

    UniProtKB/TrEMBL
    A0A8V0Z2Y7
    Conserved Domains (5) summary
    PTZ00322
    Location:659 → 743
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd07638
    Location:22 → 221
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    cd13250
    Location:277 → 380
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:625 → 653
    ANK; ANK repeat [structural motif]
    cd08851
    Location:414 → 529
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

  3. XM_040705561.2 → XP_040561495.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A3Q2U396
    Conserved Domains (6) summary
    PTZ00322
    Location:687 → 771
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd07638
    Location:22 → 221
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    COG5347
    Location:410 → 642
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    cd13250
    Location:277 → 373
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:653 → 681
    ANK; ANK repeat [structural motif]
    cd08851
    Location:407 → 522
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

  4. XM_046898414.1 → XP_046754370.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X10

    UniProtKB/TrEMBL
    A0A8V0Z2Y7

  5. XM_040705560.2 → XP_040561494.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A3Q2U396
    Conserved Domains (6) summary
    PTZ00322
    Location:690 → 774
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd07638
    Location:22 → 221
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    COG5347
    Location:413 → 645
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    cd13250
    Location:273 → 376
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:656 → 684
    ANK; ANK repeat [structural motif]
    cd08851
    Location:410 → 525
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

  6. XM_040705564.2 → XP_040561498.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X9

    UniProtKB/TrEMBL
    A0A8V0Z2Y7
    Conserved Domains (5) summary
    PTZ00322
    Location:655 → 739
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd07638
    Location:22 → 221
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    cd13250
    Location:273 → 376
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:621 → 649
    ANK; ANK repeat [structural motif]
    cd08851
    Location:410 → 525
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

  7. XM_040705562.2 → XP_040561496.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A3Q2U396
    Conserved Domains (6) summary
    PTZ00322
    Location:683 → 767
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd07638
    Location:22 → 221
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    COG5347
    Location:406 → 638
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    cd13250
    Location:273 → 369
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:649 → 677
    ANK; ANK repeat [structural motif]
    cd08851
    Location:403 → 518
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

  8. XM_040705566.2 → XP_040561500.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X11

    UniProtKB/TrEMBL
    A0A8V0Z2Y7
    Related
    ENSGALP00010024814.1, ENSGALT00010042325.1
    Conserved Domains (5) summary
    PTZ00322
    Location:648 → 732
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd07638
    Location:22 → 221
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    cd13250
    Location:273 → 369
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:614 → 642
    ANK; ANK repeat [structural motif]
    cd08851
    Location:403 → 518
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

  9. XM_015291391.4 → XP_015146877.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A3Q2U396
    Conserved Domains (8) summary
    cd07638
    Location:18 → 217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    COG5347
    Location:413 → 645
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    cd00204
    Location:656 → 774
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:273 → 376
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:271 → 372
    PH; PH domain
    pfam01412
    Location:410 → 528
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:658 → 752
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:656 → 684
    ANK; ANK repeat [structural motif]

  10. XM_015291392.4 → XP_015146878.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A3Q2U396
    Conserved Domains (8) summary
    cd07638
    Location:18 → 217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    COG5347
    Location:409 → 641
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    cd00204
    Location:652 → 770
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:269 → 372
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:267 → 368
    PH; PH domain
    pfam01412
    Location:406 → 524
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:654 → 748
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:652 → 680
    ANK; ANK repeat [structural motif]

  11. XM_015291394.4 → XP_015146880.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A3Q2U396
    Related
    ENSGALP00010024810.1, ENSGALT00010042320.1
    Conserved Domains (8) summary
    cd07638
    Location:18 → 217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    COG5347
    Location:402 → 634
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    cd00204
    Location:645 → 763
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:269 → 365
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:267 → 361
    PH; PH domain
    pfam01412
    Location:399 → 517
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:647 → 741
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:645 → 673
    ANK; ANK repeat [structural motif]

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    12181096..12237791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046923854.1 → XP_046779810.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q2U396

  2. XM_046923861.1 → XP_046779817.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

    UniProtKB/TrEMBL
    A0A8V0Z2Y7

  3. XM_046923857.1 → XP_046779813.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A3Q2U396

  4. XM_046923863.1 → XP_046779819.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X10

    UniProtKB/TrEMBL
    A0A8V0Z2Y7

  5. XM_046923856.1 → XP_046779812.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A3Q2U396

  6. XM_046923862.1 → XP_046779818.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X9

    UniProtKB/TrEMBL
    A0A8V0Z2Y7

  7. XM_046923859.1 → XP_046779815.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A3Q2U396

  8. XM_046923864.1 → XP_046779820.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X11

    UniProtKB/TrEMBL
    A0A8V0Z2Y7

  9. XM_046923855.1 → XP_046779811.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A3Q2U396

  10. XM_046923858.1 → XP_046779814.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A3Q2U396

  11. XM_046923860.1 → XP_046779816.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A3Q2U396
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5ZK62.1 GenPept UniProtKB/Swiss-Prot:Q5ZK62

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