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Cortactin cortactin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42491, updated on 4-Jan-2025

Summary

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Official Symbol
Cortactinprovided by FlyBase
Official Full Name
cortactinprovided by FlyBase
Primary source
FLYBASE:FBgn0025865
Locus tag
Dmel_CG3637
See related
AllianceGenome:FB:FBgn0025865
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3637; cortactin; cttn; Dmel\CG3637
Summary
Enables proline-rich region binding activity. Involved in oogenesis; positive regulation of cellular component organization; and protein localization to actin cytoskeleton. Located in several cellular components, including actin cap; lamellipodium; and sperm individualization complex. Part of protein-containing complex. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut primordium; epithelium; and gut section. Orthologous to several human genes including CTTN (cortactin). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Cortactin in Genome Data Viewer
Location:
93B8-93B9; 3-70 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21061680..21064471, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16887402..16890193, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Juvenile hormone binding protein 15 Neighboring gene Malvolio Neighboring gene Annexin B9 Neighboring gene rudimentary-like Neighboring gene doublesex-Mab related 93B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genomic organization, transcription start sites, and chromosomal location of the Drosophila cortactin gene. Katsube T, et al. Genes Genet Syst, 2001 Apr. PMID 11434460
  2. The Drosophila protein, Nausicaa, regulates lamellipodial actin dynamics in a Cortactin-dependent manner. O'Connell ME, et al. Biol Open, 2019 Jun 17. PMID 31164339, Free PMC Article
  3. Wear and tear of the intestinal visceral musculature by intrinsic and extrinsic factors. Kim HD, et al. Dev Dyn, 2022 Aug. PMID 35355366, Free PMC Article
  4. Myosin VI regulates actin structure specialization through conserved cargo-binding domain sites. Isaji M, et al. PLoS One, 2011. PMID 21853045, Free PMC Article
  5. Cortactin modulates cell migration and ring canal morphogenesis during Drosophila oogenesis. Somogyi K, et al. Mech Dev, 2004 Jan. PMID 14706700

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proline-rich region binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in female germline ring canal formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of receptor-mediated endocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in actin cap IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in site of polarized growth IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm individualization complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cortactin
Names
CG3637-PA
CG3637-PB
CG3637-PC
CG3637-PD
Cortactin-PA
Cortactin-PB
Cortactin-PC
Cortactin-PD
DCortactin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21061680..21064471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260295.1 → NP_001247224.1  cortactin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247224.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96046, Q9VDF4
    Conserved Domains (3) summary
    cd11959
    Location:502 → 554
    SH3_Cortactin; Src homology 3 domain of Cortactin
    PRK10811
    Location:327 → 489
    rne; ribonuclease E; Reviewed
    pfam02218
    Location:158 → 193
    HS1_rep; Repeat in HS1/Cortactin

  2. NM_001260294.1 → NP_001247223.1  cortactin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247223.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96046, Q9VDF4
    Conserved Domains (3) summary
    cd11959
    Location:502 → 554
    SH3_Cortactin; Src homology 3 domain of Cortactin
    PRK10811
    Location:327 → 489
    rne; ribonuclease E; Reviewed
    pfam02218
    Location:158 → 193
    HS1_rep; Repeat in HS1/Cortactin

  3. NM_079702.3 → NP_524426.2  cortactin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524426.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96046, Q9VDF4
    Related
    FBpp0083441
    Conserved Domains (3) summary
    cd11959
    Location:502 → 554
    SH3_Cortactin; Src homology 3 domain of Cortactin
    PRK10811
    Location:327 → 489
    rne; ribonuclease E; Reviewed
    pfam02218
    Location:158 → 193
    HS1_rep; Repeat in HS1/Cortactin

  4. NM_001260293.2 → NP_001247222.1  cortactin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247222.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96046, Q9VDF4
    Conserved Domains (3) summary
    cd11959
    Location:502 → 554
    SH3_Cortactin; Src homology 3 domain of Cortactin
    PRK10811
    Location:327 → 489
    rne; ribonuclease E; Reviewed
    pfam02218
    Location:158 → 193
    HS1_rep; Repeat in HS1/Cortactin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O96046 O96046
Q9VDF4 Q9VDF4

Gene LinkOut

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