r-l rudimentary-like [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: r-lprovided by FlyBase
Official Full Name: rudimentary-likeprovided by FlyBase
Primary source: FLYBASE:FBgn0003257
Locus tag: Dmel_CG3593
See related: AllianceGenome:FB:FBgn0003257
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3593; Dmel\CG3593; OMPDC; OPRT; ral; UMPS
Summary: Enables orotate phosphoribosyltransferase activity and orotidine-5'-phosphate decarboxylase activity. Predicted to be involved in UMP biosynthetic process and pyrimidine nucleobase biosynthetic process. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; gut section; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in orotic aciduria and purine-pyrimidine metabolic disorder. Orthologous to human UMPS (uridine monophosphate synthetase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21070557..21073319, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16896279..16899041, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables orotate phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables orotate phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables orotate phosphoribosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables orotidine-5'-phosphate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables orotidine-5'-phosphate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables orotidine-5'-phosphate decarboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in 'de novo' UMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IC Inferred by Curator more info	PubMed
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyrimidine nucleobase biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

NP_524427.1

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The following sections contain reference sequences that belong to a specific genome build. Explain