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ECT2 epithelial cell transforming 2 [ Gallus gallus (chicken) ]

Gene ID: 424983, updated on 3-Dec-2024

Summary

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Symbol
ECT2provided by CGNC
Full Name
epithelial cell transforming 2provided by CGNC
Primary source
CGNC:6968
See related
Ensembl:ENSGALG00010018517
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See ECT2 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
25
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (18928399..18955523, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (18716611..18743711, complement)

Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene neuroligin 1 Neighboring gene spermatogenesis associated 16 Neighboring gene neutral cholesterol ester hydrolase 1 Neighboring gene tumor necrosis factor superfamily member 10 Neighboring gene growth hormone secretagogue receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cytokinesis, actomyosin contractile ring assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein ECT2
Names
epithelial cell transforming sequence 2 oncogene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    18928399..18955523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040706075.2 → XP_040562009.1  protein ECT2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z6G2
    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  2. XM_015291706.4 → XP_015147192.1  protein ECT2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z6G2, E1BWT7
    Conserved Domains (4) summary
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    pfam00533
    Location:266 → 341
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam00621
    Location:456 → 640
    RhoGEF; RhoGEF domain
    pfam12738
    Location:179 → 242
    PTCB-BRCT; twin BRCT domain

  3. XM_015291707.4 → XP_015147193.1  protein ECT2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z6G2
    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  4. XM_004943470.5 → XP_004943527.1  protein ECT2 isoform X1

    See identical proteins and their annotated locations for XP_004943527.1

    UniProtKB/TrEMBL
    A0A8V0Z6G2, E1BWT7
    Related
    ENSGALP00010026735.1, ENSGALT00010044813.1
    Conserved Domains (4) summary
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    pfam00533
    Location:266 → 341
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam00621
    Location:456 → 640
    RhoGEF; RhoGEF domain
    pfam12738
    Location:179 → 242
    PTCB-BRCT; twin BRCT domain

  5. XM_040706074.2 → XP_040562008.1  protein ECT2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z6G2
    Related
    ENSGALP00010026731.1, ENSGALT00010044809.1
    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  6. XM_004943469.5 → XP_004943526.1  protein ECT2 isoform X1

    See identical proteins and their annotated locations for XP_004943526.1

    UniProtKB/TrEMBL
    A0A8V0Z6G2, E1BWT7
    Conserved Domains (4) summary
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    pfam00533
    Location:266 → 341
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam00621
    Location:456 → 640
    RhoGEF; RhoGEF domain
    pfam12738
    Location:179 → 242
    PTCB-BRCT; twin BRCT domain

  7. XM_046898490.1 → XP_046754446.1  protein ECT2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z6G2, E1BWT7

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    18716611..18743711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040679542.2 → XP_040535476.1  protein ECT2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z6G2
    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  2. XM_040679539.2 → XP_040535473.1  protein ECT2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z6G2
    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  3. XM_040679540.2 → XP_040535474.1  protein ECT2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z6G2
    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  4. XM_040679536.2 → XP_040535470.1  protein ECT2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z6G2
    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  5. XM_040679541.2 → XP_040535475.1  protein ECT2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z6G2
    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  6. XM_040679537.2 → XP_040535471.1  protein ECT2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z6G2
    Conserved Domains (4) summary
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
Nucleotide Protein
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