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Nelf-A Negative elongation factor A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42520, updated on 9-Dec-2024

Summary

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Official Symbol
Nelf-Aprovided by FlyBase
Official Full Name
Negative elongation factor Aprovided by FlyBase
Primary source
FLYBASE:FBgn0038872
Locus tag
Dmel_CG5874
See related
AllianceGenome:FB:FBgn0038872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:SD07139; CG5874; Dmel\CG5874; NELF; NELF A; nelf-A; NELF-A; NelfA
Summary
Predicted to enable RNA binding activity. Involved in negative regulation of transcription elongation by RNA polymerase II. Located in nucleus. Part of NELF complex. Orthologous to human NELFA (negative elongation factor complex member A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Nelf-A in Genome Data Viewer
Location:
93C7-93C7; 3-71 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21223704..21229512)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17049426..17055234)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing, class 5 Neighboring gene O-GlcNAcase Neighboring gene long non-coding RNA:CR44265 Neighboring gene uncharacterized protein Neighboring gene ebony Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of the chromatin landscape and RNA polymerase II binding at SIN3-regulated genes. Soukar I, et al. Biol Open, 2023 Nov 15. PMID 37850739, Free PMC Article
  2. Promoter proximal pausing and the control of gene expression. Li J, et al. Curr Opin Genet Dev, 2011 Apr. PMID 21324670, Free PMC Article
  3. The NELF pausing checkpoint mediates the functional divergence of Cdk9. DeBerardine M, et al. Nat Commun, 2023 May 13. PMID 37179384, Free PMC Article
  4. NELF-A controls Drosophila healthspan by regulating heat-shock protein-mediated cellular protection and heterochromatin maintenance. Ngian ZK, et al. Aging Cell, 2021 May. PMID 33788376, Free PMC Article
  5. Interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex. Missra A, et al. Proc Natl Acad Sci U S A, 2010 Jun 22. PMID 20534440, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The NELF pausing checkpoint mediates the functional divergence of Cdk9.
    Title: The NELF pausing checkpoint mediates the functional divergence of Cdk9.
  2. NELF-A controls Drosophila healthspan by regulating heat-shock protein-mediated cellular protection and heterochromatin maintenance.
    Title: NELF-A controls Drosophila healthspan by regulating heat-shock protein-mediated cellular protection and heterochromatin maintenance.
  3. The finding that both phenotypes of arrested embryos are obtained in embryos that lack maternally provided NELF-A as well as in embryos with reduced levels of maternal NELF-E show that these phenotypes result from the reduced activity of the NELF complex.
    Title: NELF potentiates gene transcription in the Drosophila embryo.
  4. analysis of the interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex
    Title: Interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of NELF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NELF complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription repressor complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
negative elongation factor A
Names
CG5874-PA
CG5874-PB
CG5874-PC
NELF-A
Nelf-A-PA
Nelf-A-PB
Nelf-A-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21223704..21229512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275875.1 → NP_001262804.1  negative elongation factor A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262804.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGH5

  2. NM_142701.2 → NP_650958.2  negative elongation factor A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650958.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86NP2, Q9VDC7
    UniProtKB/TrEMBL
    A0A0H4Y1G0

  3. NM_001300509.1 → NP_001287438.1  negative elongation factor A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287438.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LIF3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGH5 A0A0B4KGH5
A0A0B4LIF3 A0A0B4LIF3
Q86NP2.2 Q86NP2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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