ETHR ETHR [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ETHRprovided by FlyBase
Official Full Name: ETHRprovided by FlyBase
Primary source: FLYBASE:FBgn0038874
Locus tag: Dmel_CG5911
See related: AllianceGenome:FB:FBgn0038874
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0170980.37; anon-WO0170980.38; CG5911; CG5911a; CG5911b; Dm ETHRa; Dmel\CG5911; ETH R; ETH-R
Summary: Enables ecdysis-triggering hormone receptor activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in larval midline neurons; midline glial cell; neurons; pupal central nervous system; and ventral midline of embryo. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 7 and hypertension. Orthologous to human TRHR (thyrotropin releasing hormone receptor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21247011..21265134)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (17072733..17090856)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables G protein-coupled amine receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled peptide receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables ecdysis-triggering hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ecdysis-triggering hormone receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide receptor activity	ISM Inferred from Sequence Model more info	PubMed
enables thyrotropin-releasing hormone receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISM Inferred from Sequence Model more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed

Names: CG5911-PA; CG5911-PB; CG5911-PC; ETH receptor; ETHR-PA; ETHR-PB; ETHR-PC; Ecdysis-triggering hormone receptor; ecdysis triggering hormone receptor

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The following sections contain reference sequences that belong to a specific genome build. Explain