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AP-2sigma Adaptor Protein complex 2, sigma subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42525, updated on 9-Dec-2024

Summary

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Official Symbol
AP-2sigmaprovided by FlyBase
Official Full Name
Adaptor Protein complex 2, sigma subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0043012
Locus tag
Dmel_CG6056
See related
AllianceGenome:FB:FBgn0043012
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AP-2 sigma; AP2; AP2-sigma; aps2; cg6056; CG6056; Dmel\CG6056; sigma2; sigma2-ada
Summary
Enables clathrin adaptor activity. Involved in endocytosis. Part of AP-2 adaptor complex. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval garland cell; garland cell primordium; and posterior endoderm. Human ortholog(s) of this gene implicated in familial hypocalciuric hypercalcemia 3. Orthologous to human AP2S1 (adaptor related protein complex 2 subunit sigma 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See AP-2sigma in Genome Data Viewer
Location:
93D2-93D2; 3-71 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21269209..21270075, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17094931..17095797, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ETHR Neighboring gene antisense RNA:CR45798 Neighboring gene Rab1 Neighboring gene uncharacterized protein Neighboring gene Isopentenyl-diphosphate delta isomerase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AP2 Regulates Thickveins Trafficking to Attenuate NMJ Growth Signaling in Drosophila. Choudhury SD, et al. eNeuro, 2022 Sep-Oct. PMID 36180220, Free PMC Article
  2. AP-2-complex-mediated endocytosis of Drosophila Crumbs regulates polarity by antagonizing Stardust. Lin YH, et al. J Cell Sci, 2015 Dec 15. PMID 26527400
  3. Distinct requirements for the AP-3 adaptor complex in pigment granule and synaptic vesicle biogenesis in Drosophila melanogaster. Mullins C, et al. Mol Gen Genet, 2000 Jul. PMID 10954086
  4. Exocytosis by vesicle crumpling maintains apical membrane homeostasis during exocrine secretion. Kamalesh K, et al. Dev Cell, 2021 Jun 7. PMID 34102104, Free PMC Article
  5. A juxtamembrane basolateral targeting motif regulates signaling through a TGF-β pathway receptor in Drosophila. Peterson AJ, et al. PLoS Biol, 2022 May. PMID 35594316, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables clathrin adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables clathrin adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of AP-2 adaptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of AP-2 adaptor complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
adaptor protein complex 2, sigma subunit
Names
AP-2sigma-PA
CG6056-PA
angur
clathrin AP-2 complex
sigma2-adaptin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21269209..21270075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142704.3 → NP_650961.2  adaptor protein complex 2, sigma subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650961.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GQM7, Q9VDC3
    Related
    FBpp0083502
    Conserved Domains (1) summary
    cd14833
    Location:1 → 141
    AP2_sigma; AP-2 complex subunit sigma
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GQM7 Q9GQM7
Q9VDC3 Q9VDC3

Gene LinkOut

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