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CG3301 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42528, updated on 2-Nov-2024

Summary

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Official Symbol
CG3301provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0038878
Locus tag
Dmel_CG3301
See related
AllianceGenome:FB:FBgn0038878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG3301; FOHSDR
Summary
Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Is expressed in adult head. Orthologous to human DHRS11 (dehydrogenase/reductase 11). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG3301 in Genome Data Viewer
Location:
93D2-93D2; 3-71 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21274243..21276249, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17099965..17101971, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Adaptor Protein complex 2, sigma subunit Neighboring gene uncharacterized protein Neighboring gene Isopentenyl-diphosphate delta isomerase Neighboring gene SIFamide receptor Neighboring gene uncharacterized protein Neighboring gene Heat shock RNA omega Neighboring gene mir-4951 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inhibition of mevalonate pathway by macrophage-specific delivery of atorvastatin prevents their pro-inflammatory polarisation. Krejčová G, et al. Insect Mol Biol, 2024 Aug. PMID 38367277
  2. PRE-mediated bypass of two Su(Hw) insulators targets PcG proteins to a downstream promoter. Comet I, et al. Dev Cell, 2006 Jul. PMID 16824958
  3. Functional analysis of PGRP-LA in Drosophila immunity. Gendrin M, et al. PLoS One, 2013. PMID 23922788, Free PMC Article
  4. Genome-wide transcription profile of field- and laboratory-selected dichlorodiphenyltrichloroethane (DDT)-resistant Drosophila. Pedra JH, et al. Proc Natl Acad Sci U S A, 2004 May 4. PMID 15118106, Free PMC Article
  5. Intestinal response to dietary manganese depletion in Drosophila. Vásquez-Procopio J, et al. Metallomics, 2020 Feb 1. PMID 31799578

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 17-beta-ketosteroid reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 3-keto sterol reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG3301-PA
CG3301-PB
CG3301-PC
NP_001287440.1
NP_650964.1
NP_732612.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21274243..21276249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169954.2 → NP_732612.1  uncharacterized protein Dmel_CG3301, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732612.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VDC0
    Related
    FBpp0083500
    Conserved Domains (2) summary
    COG4221
    Location:1 → 250
    YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
    cl21454
    Location:1 → 245
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_142707.3 → NP_650964.1  uncharacterized protein Dmel_CG3301, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650964.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VDC0
    Related
    FBpp0083499
    Conserved Domains (2) summary
    COG4221
    Location:1 → 250
    YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
    cl21454
    Location:1 → 245
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. NM_001300511.1 → NP_001287440.1  uncharacterized protein Dmel_CG3301, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287440.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VDC0
    Conserved Domains (2) summary
    COG4221
    Location:1 → 250
    YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
    cl21454
    Location:1 → 245
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VDC0 Q9VDC0

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