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Cby Chibby [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42574, updated on 9-Dec-2024

Summary

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Official Symbol
Cbyprovided by FlyBase
Official Full Name
Chibbyprovided by FlyBase
Primary source
FLYBASE:FBgn0067317
Locus tag
Dmel_CG13415
See related
AllianceGenome:FB:FBgn0067317
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cby; CBY; CG13415; Dmel\CG13415
Summary
Involved in cilium assembly and protein localization to ciliary transition zone. Located in ciliary basal body; ciliary cap; and ciliary transition zone. Colocalizes with centriole. Orthologous to human CBY1 (chibby 1, beta catenin antagonist). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Cby in Genome Data Viewer
Location:
93F14-93F14; 3-73 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21868003..21868770)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17693725..17694492)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45645 Neighboring gene larsen Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Small changes in Wnt signalling. Greaves S. Nat Cell Biol, 2003 May. PMID 12724772
  2. Role of DZIP1-CBY-FAM92 transition zone complex in the basal body to membrane attachment and ciliary budding. Lapart JA, et al. Biochem Soc Trans, 2020 Jun 30. PMID 32491167
  3. Drosophila transition fibers are essential for IFT-dependent ciliary elongation but not basal body docking and ciliary budding. Hou Y, et al. Curr Biol, 2023 Feb 27. PMID 36669498
  4. Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway. Takemaru K, et al. Nature, 2003 Apr 24. PMID 12712206
  5. A nuclear function for armadillo/beta-catenin. Tolwinski NS, et al. PLoS Biol, 2004 Apr. PMID 15024404, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in axoneme assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ciliary basal body-plasma membrane docking IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ciliary transition zone assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in non-motile cilium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to ciliary transition zone IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT involved_in regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm axoneme assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary cap IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary transition zone IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chibby
Names
CG13415-PC
CG13415-PE
Cby-PC
Cby-PE
NP_001262813.1
  • deletion mutation
NP_650989.7
  • frameshift

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21868003..21868770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142732.3 → NP_650989.7  chibby, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    B9A0M5, Q4V6B6, Q9VD70

  2. NM_001275884.1 → NP_001262813.1  chibby, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262813.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHL3
    Conserved Domains (1) summary
    cd07429
    Location:1 → 99
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHL3 A0A0B4KHL3
B9A0M5 B9A0M5

Gene LinkOut

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