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Qsox2 Quiescin sulfhydryl oxidase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42583, updated on 4-Jan-2025

Summary

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Official Symbol
Qsox2provided by FlyBase
Official Full Name
Quiescin sulfhydryl oxidase 2provided by FlyBase
Primary source
FLYBASE:FBgn0038919
Locus tag
Dmel_CG17843
See related
AllianceGenome:FB:FBgn0038919
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.66; CG17843; Dmel\CG17843; DmQSOX2; Erv1
Summary
Predicted to enable flavin-dependent sulfhydryl oxidase activity and protein disulfide isomerase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head and male accessory gland. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1) and QSOX2 (quiescin sulfhydryl oxidase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Qsox2 in Genome Data Viewer
Location:
93F14-93F14; 3-73 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21913747..21915546)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17739469..17741268)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Quiescin sulfhydryl oxidase 3 Neighboring gene Ecdysone-induced protein 93F Neighboring gene Testicular haploid expressed gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. Thorpe C, et al. Arch Biochem Biophys, 2002 Sep 1. PMID 12176051
  2. Identification of potential pathways and biomarkers linked to progression in ALS. Huber RG, et al. Ann Clin Transl Neurol, 2023 Feb. PMID 36533811, Free PMC Article
  3. Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation. Liu J, et al. Hereditas, 2022 Oct 21. PMID 36271387, Free PMC Article
  4. Comparative structural modeling and inference of conserved protein classes in Drosophila seminal fluid. Mueller JL, et al. Proc Natl Acad Sci U S A, 2004 Sep 14. PMID 15345744, Free PMC Article
  5. Genome-wide mapping of in vivo targets of the Drosophila transcription factor Kruppel. Matyash A, et al. J Biol Chem, 2004 Jul 16. PMID 15131112

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables flavin-dependent sulfhydryl oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin-dependent sulfhydryl oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin-dependent sulfhydryl oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables oxidoreductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein disulfide isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sexual reproduction HEP PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
quiescin sulfhydryl oxidase 2
Names
CG17843-PA
Qsox2-PA
NP_650998.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21913747..21915546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142741.4 → NP_650998.1  quiescin sulfhydryl oxidase 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650998.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VD61
    Related
    FBpp0083548
    Conserved Domains (2) summary
    cd02992
    Location:40 → 152
    PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
    pfam04777
    Location:413 → 504
    Evr1_Alr; Erv1 / Alr family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VD61 Q9VD61

Gene LinkOut

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