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Cchl Cytochrome c heme lyase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42590, updated on 4-Jan-2025

Summary

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Official Symbol
Cchlprovided by FlyBase
Official Full Name
Cytochrome c heme lyaseprovided by FlyBase
Primary source
FLYBASE:FBgn0038925
Locus tag
Dmel_CG6022
See related
AllianceGenome:FB:FBgn0038925
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cchl; cchL; CG6022; Dmel\CG6022
Summary
Predicted to enable holocytochrome-c synthase activity. Predicted to be located in mitochondrial intermembrane space. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval muscle cell; and larval muscle system. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 1 and microphthalmia. Orthologous to human HCCS (holocytochrome c synthase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Cchl in Genome Data Viewer
Location:
94A1-94A1; 3-74 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22025975..22027480, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17851697..17853202, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mitofilin Neighboring gene mitochondrial ribosomal protein L35 Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 42 kDa subunit Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function. Liao TS, et al. Genetics, 2006 Sep. PMID 16849596, Free PMC Article
  2. A Common Suite of Coagulation Proteins Function in Drosophila Muscle Attachment. Green N, et al. Genetics, 2016 Nov. PMID 27585844, Free PMC Article
  3. Introgression in the Drosophila subobscura--D. Madeirensis sister species: evidence of gene flow in nuclear genes despite mitochondrial differentiation. Herrig DK, et al. Evolution, 2014 Mar. PMID 24152112, Free PMC Article
  4. A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila. Muerdter F, et al. Mol Cell, 2013 Jun 6. PMID 23665228, Free PMC Article
  5. Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor. Miozzo F, et al. Nat Commun, 2022 Mar 17. PMID 35301315, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables holocytochrome-c synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables holocytochrome-c synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables holocytochrome-c synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cytochrome c heme lyase
Names
CG6022-PA
CG6022-PB
Cchl-PA
Cchl-PB
cytochrome c haem lyase
NP_001262820.1
NP_651003.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22025975..22027480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142746.3 → NP_651003.1  cytochrome c heme lyase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651003.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VD55
    Related
    FBpp0083583
    Conserved Domains (1) summary
    pfam01265
    Location:13 → 260
    Cyto_heme_lyase; Cytochrome c/c1 heme lyase

  2. NM_001275891.1 → NP_001262820.1  cytochrome c heme lyase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262820.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VD55
    Conserved Domains (1) summary
    pfam01265
    Location:13 → 260
    Cyto_heme_lyase; Cytochrome c/c1 heme lyase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VD55 Q9VD55

Gene LinkOut

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