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ZAP1 zinc finger antiviral protein 1 [ Gallus gallus (chicken) ]

Gene ID: 426315, updated on 3-Dec-2024

Summary

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Official Symbol
ZAP1provided by CGNC
Official Full Name
zinc finger antiviral protein 1provided by CGNC
Primary source
CGNC:10406
See related
Ensembl:ENSGALG00010023107
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
ZAP; chZAP; ZC3HAV1
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Genomic context

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See ZAP1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
15
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (71455939..71482021, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (71769452..71794729, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene polycystic kidney disease and receptor for egg jelly-related protein-like Neighboring gene tetratricopeptide repeat protein 38 Neighboring gene uncharacterized LOC101749705 Neighboring gene uncharacterized LOC112530121

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The CCCH-Type Zinc Finger Antiviral Protein Relieves Immunosuppression of T Cells Induced by Avian Leukosis Virus Subgroup J via the NLP-PKC-δ-NFAT Pathway. Zhu M, et al. J Virol, 2022 Jan 26. PMID 34705559, Free PMC Article
  2. CCCH-type zinc finger antiviral protein mediates antiviral immune response by activating T cells. Zhu M, et al. J Leukoc Biol, 2020 Feb. PMID 31945209
  3. Characterisation of chicken ZAP. Goossens KE, et al. Dev Comp Immunol, 2014 Oct. PMID 24877657
  4. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The CCCH-Type Zinc Finger Antiviral Protein Relieves Immunosuppression of T Cells Induced by Avian Leukosis Virus Subgroup J via the NLP-PKC-delta-NFAT Pathway.
    Title: The CCCH-Type Zinc Finger Antiviral Protein Relieves Immunosuppression of T Cells Induced by Avian Leukosis Virus Subgroup J via the NLP-PKC-δ-NFAT Pathway.
  2. Chicken ZAP is upregulated in vivo following particular viral infections.
    Title: Characterisation of chicken ZAP.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
zinc finger CCCH-type antiviral protein 1
Names
zinc finger CCCH-type containing, antiviral 1
zinc finger CCCH-type, antiviral 1
zinc finger antiviral protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012938.2 → NP_001012956.2  zinc finger CCCH-type antiviral protein 1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000012
    UniProtKB/TrEMBL
    Q5F3B3
    Related
    ENSGALP00010034090.1, ENSGALT00010056317.1
    Conserved Domains (2) summary
    cd01439
    Location:587 → 703
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cl02729
    Location:409 → 491
    WWE; WWE domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    71455939..71482021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015290611.4 → XP_015146097.2  zinc finger CCCH-type antiviral protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZUF0, Q5F3B3
    Related
    ENSGALP00010034083.1, ENSGALT00010056308.1
    Conserved Domains (2) summary
    cd01439
    Location:555 → 671
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cl02729
    Location:377 → 459
    WWE; WWE domain

  2. XM_015290605.4 → XP_015146091.2  zinc finger CCCH-type antiviral protein 1 isoform X2

    UniProtKB/TrEMBL
    Q5F3B3
    Conserved Domains (2) summary
    cd01439
    Location:578 → 694
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cl02729
    Location:400 → 482
    WWE; WWE domain

  3. XM_015290600.4 → XP_015146086.2  zinc finger CCCH-type antiviral protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZRG1, Q5F3B3
    Related
    ENSGALP00010034097.1, ENSGALT00010056325.1
    Conserved Domains (2) summary
    cd01439
    Location:588 → 704
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cl02729
    Location:410 → 492
    WWE; WWE domain

  4. XM_040701065.2 → XP_040556999.1  zinc finger CCCH-type antiviral protein 1 isoform X4

    Conserved Domains (1) summary
    cl02729
    Location:410 → 492
    WWE; WWE domain

  5. XM_025150957.3 → XP_025006725.2  zinc finger CCCH-type antiviral protein 1 isoform X9

    Conserved Domains (1) summary
    cl02729
    Location:400 → 482
    WWE; WWE domain

  6. XM_040701074.2 → XP_040557008.1  zinc finger CCCH-type antiviral protein 1 isoform X8

    Conserved Domains (1) summary
    cl02729
    Location:409 → 491
    WWE; WWE domain

  7. XM_025150955.3 → XP_025006723.2  zinc finger CCCH-type antiviral protein 1 isoform X6

    Conserved Domains (1) summary
    cl02729
    Location:410 → 492
    WWE; WWE domain

  8. XM_015290630.4 → XP_015146116.2  zinc finger CCCH-type antiviral protein 1 isoform X7

    Conserved Domains (1) summary
    cl02729
    Location:410 → 492
    WWE; WWE domain

  9. XM_015290625.4 → XP_015146111.2  zinc finger CCCH-type antiviral protein 1 isoform X5

    Conserved Domains (1) summary
    cl02729
    Location:410 → 492
    WWE; WWE domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    71769452..71794729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046908518.1 → XP_046764474.1  zinc finger CCCH-type antiviral protein 1 isoform X3

    UniProtKB/TrEMBL
    Q5F3B3

  2. XM_046908517.1 → XP_046764473.1  zinc finger CCCH-type antiviral protein 1 isoform X2

    UniProtKB/TrEMBL
    Q5F3B3

  3. XM_046908516.1 → XP_046764472.1  zinc finger CCCH-type antiviral protein 1 isoform X1

    UniProtKB/TrEMBL
    Q5F3B3

  4. XM_046908519.1 → XP_046764475.1  zinc finger CCCH-type antiviral protein 1 isoform X4

  5. XM_046908525.1 → XP_046764481.1  zinc finger CCCH-type antiviral protein 1 isoform X9

  6. XM_046908524.1 → XP_046764480.1  zinc finger CCCH-type antiviral protein 1 isoform X8

  7. XM_046908522.1 → XP_046764478.1  zinc finger CCCH-type antiviral protein 1 isoform X6

  8. XM_046908523.1 → XP_046764479.1  zinc finger CCCH-type antiviral protein 1 isoform X7

  9. XM_046908521.1 → XP_046764477.1  zinc finger CCCH-type antiviral protein 1 isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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