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CCT1 Chaperonin containing TCP1 subunit 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42649, updated on 9-Dec-2024

Summary

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Official Symbol
CCT1provided by FlyBase
Official Full Name
Chaperonin containing TCP1 subunit 1provided by FlyBase
Primary source
FLYBASE:FBgn0003676
Locus tag
Dmel_CG5374
See related
AllianceGenome:FB:FBgn0003676
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:GH05123; cct1; Cct1; CG5374; Dmel\CG5374; gh05123; T-cp1; T-CP1; T-cpl; Tcp-1; TCP-1alpha; tcp1; Tcp1; Tcp1-alpha; TCP1-alpha; Tcp1-like; TCP1alpha; TCPA_DROME
Summary
Predicted to enable unfolded protein binding activity. Involved in follicle cell of egg chamber development. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; adult head; embryonic/larval midgut primordium; larval muscle cell; and mesoderm. Orthologous to human TCP1 (t-complex 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CCT1 in Genome Data Viewer
Location:
94B1-94B1; 3-75 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22489105..22491439, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18314827..18317161, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Neurexin 1 Neighboring gene mir-4952 stem loop Neighboring gene Prefoldin 5 Neighboring gene uncharacterized protein Neighboring gene testis-enriched HMG-box-containing protein 1 Neighboring gene testis-enriched HMG-box-containing protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Drosophila melanogaster gene encodes a protein homologous to the mouse t complex polypeptide 1. Ursic D, et al. Gene, 1988 Sep 7. PMID 3146529
  2. Clusters of temporal discordances reveal distinct embryonic patterning mechanisms in Drosophila and anopheles. Papatsenko D, et al. PLoS Biol, 2011 Jan 25. PMID 21283609, Free PMC Article
  3. CCT complex restricts neuropathogenic protein aggregation via autophagy. Pavel M, et al. Nat Commun, 2016 Dec 8. PMID 27929117, Free PMC Article
  4. Early evolution of the bilateria. Hausdorf B. Syst Biol, 2000 Mar. PMID 12116476
  5. Chaperonin TRiC/CCT supports mitotic exit and entry into endocycle in Drosophila. Ohhara Y, et al. PLoS Genet, 2019 Apr. PMID 31034473, Free PMC Article

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. chaperonin-containing TCP-1 complex required for lysosomal functioning and autophagosome degradation
    Title: CCT complex restricts neuropathogenic protein aggregation via autophagy.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in follicle cell of egg chamber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
chaperonin containing TCP1 subunit 1
Names
CCT1-PA
CCT1-PB
CG5374-PA
CG5374-PB
T-complex 1
Tcp1-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22489105..22491439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170016.2 → NP_732748.1  chaperonin containing TCP1 subunit 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732748.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P12613, Q9VCZ6
    UniProtKB/TrEMBL
    A4V391
    Related
    FBpp0083683
    Conserved Domains (1) summary
    cd03335
    Location:12 → 538
    TCP1_alpha; TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...

  2. NM_079726.4 → NP_524450.2  chaperonin containing TCP1 subunit 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524450.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P12613, Q9VCZ6
    UniProtKB/TrEMBL
    A4V391
    Related
    FBpp0083684
    Conserved Domains (1) summary
    cd03335
    Location:12 → 538
    TCP1_alpha; TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V391 A4V391
P12613.2 P12613

Gene LinkOut

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