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mRRF2 mitochondrial ribosome recycling factor 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42670, updated on 4-Jan-2025

Summary

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Official Symbol
mRRF2provided by FlyBase
Official Full Name
mitochondrial ribosome recycling factor 2provided by FlyBase
Primary source
FLYBASE:FBgn0051159
Locus tag
Dmel_CG31159
See related
AllianceGenome:FB:FBgn0051159
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31159; CG6943; dEF-G2; Dmel\CG31159; EF-G2
Summary
Predicted to enable GTPase activity. Predicted to be involved in mitochondrial translation and ribosome disassembly. Predicted to be located in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 39. Orthologous to human GFM2 (GTP dependent ribosome recycling factor mitochondrial 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See mRRF2 in Genome Data Viewer
Location:
94B6-94B6; 3-75 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22613686..22616622)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18439408..18442344)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Exchange factor for Arf 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L45 Neighboring gene locomotion defects Neighboring gene long non-coding RNA:CR43475

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila mitochondrial translation elongation factor G1 contains a nuclear localization signal and inhibits growth and DPP signaling. Trivigno C, et al. PLoS One, 2011 Feb 25. PMID 21364917, Free PMC Article
  2. The translation factors of Drosophila melanogaster. Marygold SJ, et al. Fly (Austin), 2017 Jan 2. PMID 27494710, Free PMC Article
  3. The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Arya GH, et al. Chem Senses, 2015 May. PMID 25687947, Free PMC Article
  4. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article
  5. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosome disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome disassembly IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
mitochondrial ribosome recycling factor 2
Names
CG31159-PA
CG31159-PB
elongation factor G2
mRRF2-PA
mRRF2-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22613686..22616622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170028.3 → NP_732771.2  mitochondrial ribosome recycling factor 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732771.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3KU70, F1JZV4, Q9VCX4
    UniProtKB/TrEMBL
    I1WYH6
    Conserved Domains (1) summary
    PRK12739
    Location:31 → 733
    PRK12739; elongation factor G; Reviewed

  2. NM_001300539.1 → NP_001287468.1  mitochondrial ribosome recycling factor 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287468.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LIH0
    Conserved Domains (5) summary
    TIGR00231
    Location:33 → 202
    small_GTP; small GTP-binding protein domain
    cd16262
    Location:447 → 522
    EFG_III; Domain III of Elongation Factor G (EFG)
    cl02787
    Location:323 → 403
    Translation_Factor_II_like; Domain II of Elongation factor Tu (EF-Tu)-like proteins
    cl02789
    Location:523 → 562
    EFG_like_IV; Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily ...
    cl21455
    Location:35 → 309
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LIH0 A0A0B4LIH0
Q9VCX4.3 Q9VCX4

Gene LinkOut

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