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Nup133 Nucleoporin 133kD [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42680, updated on 9-Dec-2024

Summary

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Official Symbol
Nup133provided by FlyBase
Official Full Name
Nucleoporin 133kDprovided by FlyBase
Primary source
FLYBASE:FBgn0039004
Locus tag
Dmel_CG6958
See related
AllianceGenome:FB:FBgn0039004
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6958; Dmel\CG6958; Nup 133; nup133
Summary
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in poly(A)+ mRNA export from nucleus; protein import into nucleus; and transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Predicted to be part of nuclear pore outer ring. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and nephrotic syndrome type 18. Orthologous to human NUP133 (nucleoporin 133). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Nup133 in Genome Data Viewer
Location:
94C1-94C1; 3-76 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22690607..22694772)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18516329..18520494)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene wolfram syndrome 1 Neighboring gene cardinal Neighboring gene Cytochrome P450 6d4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel method to detect proteins evolving at correlated rates: identifying new functional relationships between coevolving proteins. Clark NL, et al. Mol Biol Evol, 2010 May. PMID 20044587, Free PMC Article
  2. Functional genomics evidence unearths new moonlighting roles of outer ring coat nucleoporins. Katsani KR, et al. Sci Rep, 2014 Apr 11. PMID 24722254, Free PMC Article
  3. Pervasive adaptive evolution among interactors of the Drosophila hybrid inviability gene, Nup96. Presgraves DC, et al. Mol Biol Evol, 2007 Jan. PMID 17056646
  4. Genetic Analyses of Elys Mutations in Drosophila Show Maternal-Effect Lethality and Interactions with Nucleoporin Genes. Hirai K, et al. G3 (Bethesda), 2018 Jul 2. PMID 29773558, Free PMC Article
  5. Specific nucleoporin requirement for Smad nuclear translocation. Chen X, et al. Mol Cell Biol, 2010 Aug. PMID 20547758, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of nuclear pore ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of nuclear pore outer ring IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore outer ring ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nucleoporin 133kD
Names
CG6958-PA
Nup133-PA
nucleoporin 133

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22690607..22694772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142823.3 → NP_651080.2  nucleoporin 133kD [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651080.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86PB8, Q961A9, Q9VCW3
    UniProtKB/TrEMBL
    A1YK77, A1YK80, A1YK85, A1YK86
    Related
    FBpp0083695
    Conserved Domains (2) summary
    pfam03177
    Location:767 → 1122
    Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal
    pfam08801
    Location:87 → 489
    Nucleoporin_N; Nup133 N terminal like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1YK77 A1YK77
A1YK78 A1YK78
A1YK79 A1YK79
A1YK80 A1YK80
A1YK81 A1YK81
A1YK82 A1YK82
A1YK83 A1YK83
A1YK85 A1YK85
A1YK86 A1YK86
Q9VCW3.2 Q9VCW3

Gene LinkOut

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