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Irp-1A Iron regulatory protein 1A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42689, updated on 9-Dec-2024

Summary

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Official Symbol
Irp-1Aprovided by FlyBase
Official Full Name
Iron regulatory protein 1Aprovided by FlyBase
Primary source
FLYBASE:FBgn0024958
Locus tag
Dmel_CG4900
See related
AllianceGenome:FB:FBgn0024958
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
c-Acon; C-Acon; cAcon; cACON; CG4900; dIRP; Dmel\CG4900; IRF; IRP; IRP-1; IRP-1A; IRP1; irp1A; IRP1A
Summary
Enables aconitate hydratase activity and iron-responsive element binding activity. Involved in intracellular iron ion homeostasis and ventral furrow formation. Located in cytosol and nucleus. Is expressed in adult head; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Used to study porphyria. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including ACO1 (aconitase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Irp-1A in Genome Data Viewer
Location:
94C3-94C3; 3-76 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22721320..22724587, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18547042..18550309, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene winged eye Neighboring gene antisense RNA:CR45648 Neighboring gene ring finger protein 220 Neighboring gene uncharacterized protein Neighboring gene Tak1-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mRNA-binding protein which controls ferritin and transferrin receptor expression is conserved during evolution. Rothenberger S, et al. Nucleic Acids Res, 1990 Mar 11. PMID 2157191, Free PMC Article
  2. Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements. Gray NK, et al. Proc Natl Acad Sci U S A, 1996 May 14. PMID 8643505, Free PMC Article
  3. Differential translational regulation of IRE-containing mRNAs in Drosophila melanogaster by endogenous IRP and a constitutive human IRP1 mutant. Surdej P, et al. Insect Biochem Mol Biol, 2008 Sep. PMID 18675912
  4. Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans. Muckenthaler M, et al. Eur J Biochem, 1998 Jun 1. PMID 9660175
  5. Drosophila ZIP13 is posttranslationally regulated by iron-mediated stabilization. Xu J, et al. Biochim Biophys Acta Mol Cell Res, 2019 Sep. PMID 31229649

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aconitate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aconitate hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aconitate hydratase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables iron-responsive element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron-responsive element binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron-responsive element binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in citrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ventral furrow formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
iron regulatory protein 1A
Names
CG4900-PA
Irp-1A-PA
c-aconitase
cytoplasmic aconitase
cytosolic aconitase
iron regulatory factor
iron regulatory protein
NP_477371.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22721320..22724587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058023.5 → NP_477371.1  iron regulatory protein 1A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477371.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NFX3, Q9VCV4
    Related
    FBpp0083720
    Conserved Domains (3) summary
    cd01586
    Location:88 → 579
    AcnA_IRP; Aconitase A catalytic domain
    cd01580
    Location:683 → 852
    AcnA_IRP_Swivel; Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group ...
    PTZ00092
    Location:1 → 901
    PTZ00092; aconitate hydratase-like protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76934 O76934
Q9NFX3 Q9NFX3
Q9VCV4 Q9VCV4

Gene LinkOut

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