U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HP1c Heterochromatin Protein 1c [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42696, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
HP1cprovided by FlyBase
Official Full Name
Heterochromatin Protein 1cprovided by FlyBase
Primary source
FLYBASE:FBgn0039019
Locus tag
Dmel_CG6990
See related
AllianceGenome:FB:FBgn0039019
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6990; Dmel\CG6990; HP1; hp1c; Hp1c; HP1C
Summary
Enables chromatin binding activity; histone reader activity; and methylated histone binding activity. Involved in regulation of transcription by RNA polymerase II and subtelomeric heterochromatin formation. Located in euchromatin; nucleus; and polytene chromosome interband. Part of protein-containing complex. Is expressed in several structures, including adult head; central brain primordium; ganglia; gonad; and larval nervous system. Orthologous to human CBX1 (chromobox 1) and CBX5 (chromobox 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See HP1c in Genome Data Viewer
Location:
94C4-94C4; 3-76 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22745620..22746605)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18571342..18572327)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Dicer-1 Neighboring gene uncharacterized protein Neighboring gene vreteno Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-specific protease 12/46 Neighboring gene rumi Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 13

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Chromatin remodeling in the aging genome of Drosophila. Wood JG, et al. Aging Cell, 2010 Dec. PMID 20961390, Free PMC Article
  2. The Ancient Origin and Function of Germline Cysts. Spradling AC. Results Probl Cell Differ, 2024. PMID 37996670
  3. The Heterochromatin Protein 1 family. Lomberk G, et al. Genome Biol, 2006. PMID 17224041, Free PMC Article
  4. The changing faces of HP1: From heterochromatin formation and gene silencing to euchromatic gene expression: HP1 acts as a positive regulator of transcription. Kwon SH, et al. Bioessays, 2011 Apr. PMID 21271610
  5. HP1c casts light on dark matter. Kwon SH, et al. Cell Cycle, 2011 Feb 15. PMID 21301224

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HP1 associates differently with RNA polymerase II; HP1a and HP1b, but not HP1c, inhibit transcriptional activity, suggesting that HP1c serves as a positive regulator in transcription.
    Title: Comparison of three heterochromatin protein 1 homologs in Drosophila.
  2. dDsk2 prevents dUbp8/Nonstop-dependent H2Bub1 deubiquitylation at promoters of dHP1c complex target genes and regulates RNA polymerase II pausing.
    Title: dDsk2 regulates H2Bub1 and RNA polymerase II pausing at dHP1c complex target genes.
  3. Data indicate significant similarity and uniqueness in the genes regulated by three HP1 homologs HP1a, HP1b, and HP1c.
    Title: DNA microarray profiling of genes differentially regulated by three heterochromatin protein 1 (HP1) homologs in Drosophila.
  4. interaction between HP1c and Woc constitutes a transcriptional feedback loop that operates to balance the concentration of HP1c within the cell
    Title: Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc.
  5. HP1c, WOC, and ROW regulate a common gene expression program that, in part, is executed in the context of the nervous system.
    Title: Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone reader activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in pericentric heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in polytene chromosome interband IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
heterochromatin protein 1c
Names
CG6990-PA
HP1c-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22745620..22746605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142836.3 → NP_651093.1  heterochromatin protein 1c [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651093.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VCU6
    Related
    FBpp0083702
    Conserved Domains (2) summary
    pfam00385
    Location:9 → 58
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
    pfam01393
    Location:89 → 134
    Chromo_shadow; Chromo shadow domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VCU6 Q9VCU6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools