U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nepl14 Neprilysin-like 14 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42700, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Nepl14provided by FlyBase
Official Full Name
Neprilysin-like 14provided by FlyBase
Primary source
FLYBASE:FBgn0039023
Locus tag
Dmel_CG4723
See related
AllianceGenome:FB:FBgn0039023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4723; Dmel\CG4723
Summary
Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Nepl14 in Genome Data Viewer
Location:
94C4-94C4; 3-76 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22761440..22763711, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18587162..18589433, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-specific protease 12/46 Neighboring gene rumi Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 13 Neighboring gene Neprilysin-like 15 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A timely expression profile. Jackson FR, et al. Dev Cell, 2001 Dec. PMID 11740934
  2. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
  3. Genome-wide view of cell fate specification: ladybird acts at multiple levels during diversification of muscle and heart precursors. Junion G, et al. Genes Dev, 2007 Dec 1. PMID 18056427, Free PMC Article
  4. Circadian regulation of gene expression systems in the Drosophila head. Claridge-Chang A, et al. Neuron, 2001 Nov 20. PMID 11719206
  5. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Neprilysin-like 14
Names
CG4723-PA
Nepl14-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22761440..22763711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142840.4 → NP_651097.1  Neprilysin-like 14 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651097.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VCU2
    Related
    FBpp0083711
    Conserved Domains (1) summary
    cd08662
    Location:60 → 693
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VCU2 Q9VCU2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous