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SYK spleen associated tyrosine kinase [ Gallus gallus (chicken) ]

Gene ID: 427272, updated on 3-Dec-2024

Summary

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Symbol
SYKprovided by CGNC
Full Name
spleen associated tyrosine kinaseprovided by CGNC
Primary source
CGNC:53036
See related
Ensembl:ENSGALG00010009340
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See SYK in Genome Data Viewer
Location:
chromosome: Z
Exon count:
15
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (44660428..44712213)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (44660428..44712213)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101748847 Neighboring gene uncharacterized LOC121108570 Neighboring gene DIRAS family GTPase 2 Neighboring gene tubulin polymerization promoting protein family member 2 Neighboring gene AU RNA binding methylglutaconyl-CoA hydratase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav. Chen CH, et al. Mol Cell Biol, 2011 Jul. PMID 21606197, Free PMC Article
  2. Generation of an analog-sensitive Syk tyrosine kinase for the study of signaling dynamics from the B cell antigen receptor. Oh H, et al. J Biol Chem, 2007 Nov 16. PMID 17913708
  3. Nonredundant roles of Src-family kinases and Syk in the initiation of B-cell antigen receptor signaling. Stepanek O, et al. J Immunol, 2013 Feb 15. PMID 23335753
  4. Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases. Chung SC, et al. J Cell Biol, 2007 Apr 23. PMID 17452533, Free PMC Article
  5. Bruton's tyrosine kinase is essential for hydrogen peroxide-induced calcium signaling. Qin S, et al. Biochemistry, 2001 Jul 10. PMID 11434777

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters
    Title: The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.
  2. Analysis of controlled B cell receptor triggering ex vivo and on primary murine B cells reveals that Src family kinases are required for signal initiation and Syk activation.
    Title: Nonredundant roles of Src-family kinases and Syk in the initiation of B-cell antigen receptor signaling.
  3. Results suggest that the uncommon recognition determinant of two closely spaced tyrosines is a limiting factor in NFAT signaling via Syk association with Vav1.
    Title: Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav.
  4. In hydrogen peroxide-stimulated DT40 cells, BLNK is phosphorylated by Syk and not by Btk.
    Title: Bruton's tyrosine kinase is essential for hydrogen peroxide-induced calcium signaling.
  5. Microarray analysis of SCA-2 induced bursal cells showed SYK to be among the under-expressed genes and this was validated with qRT-PCR.
    Title: Cloning and functional characterization of chicken stem cell antigen 2.
  6. Syk tyrosine kinase has a role in signaling dynamics of the B cell antigen receptor
    Title: Generation of an analog-sensitive Syk tyrosine kinase for the study of signaling dynamics from the B cell antigen receptor.
  7. The simultaneous but not the independent suppression of Lyn and Syk expression prevents the activation of Ca2+-release activated Ca2+ current without interfering with thapsigargin-sensitive Ca(2+) store release in DT40 B lymphocyte cells.
    Title: Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in macrophage activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neutrophil activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of B cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of alpha-beta T cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of platelet aggregation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase SYK
Names
spleen tyrosine kinase
NP_001026601.2
XP_015135783.1
XP_015135784.1
XP_046791077.1
XP_046791078.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031430.2 → NP_001026601.2  tyrosine-protein kinase SYK

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000094
    UniProtKB/Swiss-Prot
    F1N9Y5, Q5ZJ91
    UniProtKB/TrEMBL
    A0A8V0Y9Z4
    Related
    ENSGALP00010012784.1, ENSGALT00010022248.1
    Conserved Domains (3) summary
    cd05116
    Location:353 → 609
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    44660428..44712213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015280297.4 → XP_015135783.1  tyrosine-protein kinase SYK isoform X1

    UniProtKB/TrEMBL
    A0A0A0MQ53, A0A8V0Y1F7
    Related
    ENSGALP00010012791.1, ENSGALT00010022258.1
    Conserved Domains (4) summary
    cd05116
    Location:376 → 632
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
    pfam07714
    Location:371 → 627
    Pkinase_Tyr; Protein tyrosine kinase

  2. XM_015280298.4 → XP_015135784.1  tyrosine-protein kinase SYK isoform X1

    UniProtKB/TrEMBL
    A0A0A0MQ53, A0A8V0Y1F7
    Conserved Domains (4) summary
    cd05116
    Location:376 → 632
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
    pfam07714
    Location:371 → 627
    Pkinase_Tyr; Protein tyrosine kinase

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    44660428..44712213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046935121.1 → XP_046791077.1  tyrosine-protein kinase SYK isoform X1

    UniProtKB/TrEMBL
    A0A0A0MQ53, A0A8V0Y1F7

  2. XM_046935122.1 → XP_046791078.1  tyrosine-protein kinase SYK isoform X1

    UniProtKB/TrEMBL
    A0A0A0MQ53, A0A8V0Y1F7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1N9Y5.2 GenPept UniProtKB/Swiss-Prot:F1N9Y5

Gene LinkOut

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