U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

unk unkempt [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42738, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
unkprovided by FlyBase
Official Full Name
unkemptprovided by FlyBase
Primary source
FLYBASE:FBgn0004395
Locus tag
Dmel_CG4620
See related
AllianceGenome:FB:FBgn0004395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4620; Dmel\CG4620
Summary
Predicted to enable zinc ion binding activity. Involved in several processes, including chaeta morphogenesis; compound eye development; and imaginal disc-derived wing morphogenesis. Located in cytoplasm. Is expressed in several structures, including adult brain cell body rind; eye disc anterior to the morphogenetic furrow; eye disc posterior to the morphogenetic furrow; ommatidial precursor cluster; and presumptive embryonic/larval central nervous system. Orthologous to several human genes including UNK (unk zinc finger). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See unk in Genome Data Viewer
Location:
94E1-94E2; 3-78 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23149653..23157862, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18975375..18983584, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene hedgehog Neighboring gene Vacuolar H[+] ATPase AC39 subunit 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Dual role for Headcase in hemocyte progenitor fate determination in Drosophila melanogaster. Kharrat B, et al. PLoS Genet, 2024 Oct. PMID 39466810, Free PMC Article
  2. The mTOR pathway component Unkempt regulates neural stem cell and neural progenitor cell cycle in the Drosophila central nervous system. Maierbrugger KT, et al. Dev Biol, 2020 May 1. PMID 31978396
  3. Segmentally restricted, cephalic expression of a leucine zipper gene during Drosophila embryogenesis. Mohler J, et al. Mech Dev, 1991 Mar. PMID 1911393
  4. The embryonically active gene, unkempt, of Drosophila encodes a Cys3His finger protein. Mohler J, et al. Genetics, 1992 Jun. PMID 1339381, Free PMC Article
  5. Modulation of alternative splicing by long-range RNA structures in Drosophila. Raker VA, et al. Nucleic Acids Res, 2009 Aug. PMID 19465384, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mTOR pathway component Unkempt regulates neural stem cell and neural progenitor cell cycle in the Drosophila central nervous system.
    Title: The mTOR pathway component Unkempt regulates neural stem cell and neural progenitor cell cycle in the Drosophila central nervous system.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaeta morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
unkempt
Names
CG4620-PA
CG4620-PB
CG4620-PC
CG4620-PD
CG4620-PE
CG4620-PF
CG4620-PG
unk-PA
unk-PB
unk-PC
unk-PD
unk-PE
unk-PF
unk-PG

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23149653..23157862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275931.1 → NP_001262860.1  unkempt, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262860.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGS7
    Conserved Domains (3) summary
    COG3210
    Location:310 → 475
    FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
    pfam00642
    Location:273 → 299
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:553 → 598
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  2. NM_001260326.2 → NP_001247255.1  unkempt, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247255.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V397, Q24580, Q5BIG8, Q86B79, Q960U9
    UniProtKB/TrEMBL
    A0A0B4K6Y4
    Conserved Domains (3) summary
    COG3210
    Location:309 → 474
    FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
    pfam00642
    Location:273 → 299
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:552 → 597
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  3. NM_176545.3 → NP_788722.1  unkempt, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788722.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V397, Q24580, Q5BIG8, Q86B79, Q960U9
    UniProtKB/TrEMBL
    A0A0B4K6Y4
    Related
    FBpp0083794
    Conserved Domains (3) summary
    COG3210
    Location:309 → 474
    FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
    pfam00642
    Location:273 → 299
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:552 → 597
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  4. NM_001260324.2 → NP_001247253.1  unkempt, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247253.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V397, Q24580, Q5BIG8, Q86B79, Q960U9
    UniProtKB/TrEMBL
    A0A0B4K6Y4
    Conserved Domains (3) summary
    COG3210
    Location:309 → 474
    FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
    pfam00642
    Location:273 → 299
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:552 → 597
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  5. NM_001260325.2 → NP_001247254.1  unkempt, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247254.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7D1
    Conserved Domains (3) summary
    COG3210
    Location:311 → 547
    FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
    pfam00642
    Location:273 → 299
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:625 → 670
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  6. NM_001316501.1 → NP_001303430.1  unkempt, isoform G [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GV12
    Conserved Domains (3) summary
    COG3210
    Location:311 → 548
    FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
    pfam00642
    Location:273 → 299
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:626 → 671
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  7. NM_176546.3 → NP_788723.1  unkempt, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788723.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V397, Q24580, Q5BIG8, Q86B79, Q960U9
    UniProtKB/TrEMBL
    A0A0B4K6Y4
    Related
    FBpp0083795
    Conserved Domains (3) summary
    COG3210
    Location:309 → 474
    FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
    pfam00642
    Location:273 → 299
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:552 → 597
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6Y4 A0A0B4K6Y4
A0A0B4K7D1 A0A0B4K7D1
A0A0B4KGS7 A0A0B4KGS7
A0A126GV12 A0A126GV12
Q86B79.1 Q86B79

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous