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Irk1 Inwardly rectifying potassium channel 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42742, updated on 4-Jan-2025

Summary

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Official Symbol
Irk1provided by FlyBase
Official Full Name
Inwardly rectifying potassium channel 1provided by FlyBase
Primary source
FLYBASE:FBgn0265042
Locus tag
Dmel_CG44159
See related
AllianceGenome:FB:FBgn0265042
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13836; CG44159; CG6747; Dir; DIR; dIRK; dKirI; Dmel\CG44159; Dm_3R:100326; Dm_3R:100349; ir; Ir; irk1; Kir1
Old locus tag
Dmel_CG13836; Dmel_CG6747
Summary
Enables inward rectifier potassium channel activity. Involved in several processes, including locomotor rhythm; potassium ion transport; and wing disc development. Located in membrane. Is expressed in several structures, including adult head; embryonic/larval corpus cardiacum; epithelial tube; ganglia; and imaginal disc. Human ortholog(s) of this gene implicated in several diseases, including EAST syndrome; autosomal recessive nonsyndromic deafness 4; glucose metabolism disease (multiple); heart conduction disease (multiple); and long QT syndrome (multiple). Orthologous to several human genes including KCNJ5 (potassium inwardly rectifying channel subfamily J member 5) and KCNJ9 (potassium inwardly rectifying channel subfamily J member 9). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Irk1 in Genome Data Viewer
Location:
94E3-94E4; 3-78 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23168317..23185642)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18994039..19011364)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+] ATPase AC39 subunit 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene cap-n-collar Neighboring gene fuzzy onions Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of Dir: a putative potassium inward rectifying channel in Drosophila. MacLean SJ, et al. Mech Dev, 2002 Aug. PMID 12128223
  2. Role of inward rectifier potassium channels in salivary gland function and sugar feeding of the fruit fly, Drosophila melanogaster. Swale DR, et al. Pestic Biochem Physiol, 2017 Sep. PMID 28911739
  3. Inwardly Rectifying Potassium (Kir) Channels Represent a Critical Ion Conductance Pathway in the Nervous Systems of Insects. Chen R, et al. Sci Rep, 2018 Jan 25. PMID 29371678, Free PMC Article
  4. Neuronal excitability as a regulator of circuit remodeling. Mayseless O, et al. Curr Biol, 2023 Mar 13. PMID 36758544, Free PMC Article
  5. Two inwardly rectifying potassium channels, Irk1 and Irk2, play redundant roles in Drosophila renal tubule function. Wu Y, et al. Am J Physiol Regul Integr Comp Physiol, 2015 Oct. PMID 26224687, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Irk1 and Irk2 play redundant roles in transepithelial ion transport in the Drosophila melanogaster renal tubule and are additive to Na(+)/K(+)-ATPase-dependent pathways
    Title: Two inwardly rectifying potassium channels, Irk1 and Irk2, play redundant roles in Drosophila renal tubule function.
  2. Drosophila inward rectifier (Dir) is the first putative inward rectifier to be studied in Drosophila.
    Title: Characterization of Dir: a putative potassium inward rectifying channel in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
inwardly rectifying potassium channel 1
Names
CG44159-PB
CG44159-PC
CG44159-PD
CG44159-PE
CG44159-PF
CG44159-PG
CG44159-PH
Ir
Irk1-PB
Irk1-PC
Irk1-PD
Irk1-PE
Irk1-PF
Irk1-PG
Irk1-PH
drosophila inward rectifier
inwardly rectifying potassium channel

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23168317..23185642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275933.1 → NP_001262862.1  inwardly rectifying potassium channel 1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262862.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KH86, C9QPA7
    Conserved Domains (1) summary
    pfam01007
    Location:145 → 477
    IRK; Inward rectifier potassium channel

  2. NM_001275932.1 → NP_001262861.1  inwardly rectifying potassium channel 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262861.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KH86, C9QPA7
    Conserved Domains (1) summary
    pfam01007
    Location:145 → 477
    IRK; Inward rectifier potassium channel

  3. NM_001202341.1 → NP_001189270.1  inwardly rectifying potassium channel 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189270.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JCZ2, C9QPA7
    Conserved Domains (1) summary
    pfam01007
    Location:33 → 365
    IRK; Inward rectifier potassium channel

  4. NM_001104414.2 → NP_001097884.1  inwardly rectifying potassium channel 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097884.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JR87, C9QPA7
    Conserved Domains (1) summary
    pfam01007
    Location:48 → 380
    IRK; Inward rectifier potassium channel

  5. NM_001275934.1 → NP_001262863.1  inwardly rectifying potassium channel 1, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262863.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPA7, E1JIU2
    Conserved Domains (1) summary
    pfam01007
    Location:19 → 351
    IRK; Inward rectifier potassium channel

  6. NM_001170226.1 → NP_001163697.1  inwardly rectifying potassium channel 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163697.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPA7, E1JIU2
    Conserved Domains (1) summary
    pfam01007
    Location:19 → 351
    IRK; Inward rectifier potassium channel

  7. NM_142874.3 → NP_651131.2  inwardly rectifying potassium channel 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651131.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPA7, Q9VCQ0
    Related
    FBpp0307578
    Conserved Domains (1) summary
    pfam01007
    Location:25 → 357
    IRK; Inward rectifier potassium channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JCZ2 A0A0B4JCZ2
A0A0B4KH86 A0A0B4KH86
A8JR87 A8JR87
E1JIU2 E1JIU2
Q95UP7 Q95UP7
Q9VCQ0 Q9VCQ0

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